Anaphylaxis-induced premature uterine contractions: a case report and literature review.

Warintaksa, Puntabut, Lertrat, Waranyu, Romero, Roberto, Vivithanaporn, Pornpun, Mongkolsuk, Paninee, Kamlungkuea, Threebhorn, Settacomkul, Rapeewan, Pongchaikul, Pisut ORCID: 0000-0001-8757-3554 and Chaemsaithong, Piya (2024) Anaphylaxis-induced premature uterine contractions: a case report and literature review. BMC pregnancy and childbirth, 24 (1). p. 197.

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Official URL: http://dx.doi.org/10.1186/s12884-024-06297-2

Abstract

<h4>Background</h4>Preterm labor is caused by multiple etiologies, including intra-amniotic infection and/or intra-amniotic inflammation, vascular disorders, cervical disease, decidual senescence, and breakdown of maternal-fetal tolerance. Accumulating evidence in vivo and in vitro has shown that an allergic reaction, including anaphylaxis, can induce preterm uterine contractions. This report describes a case of a pregnant woman who developed anaphylaxis and regular uterine contractions after the ingestion of a strawberry-coated biscuit. We also review the mechanism of allergic reaction (hypersensitivity)-induced preterm labor. Case presentation A 31-year-old woman (gravida 1, para 0) at 30<sup>+2</sup> weeks of gestation was admitted to the labor and delivery unit with regular uterine contractions and anaphylactic symptoms after she ingested a strawberry-coated biscuit as a snack. The uterine contractions resolved after the treatment of anaphylaxis by administering antihistamines and epinephrine. The patient subsequently delivered at 39<sup>+3</sup> weeks of gestation. The amniotic fluid profile showed no infection or inflammation. A postpartum skin-prick test confirmed a positive type 1 hypersensitivity reaction to the strawberry-coated biscuit.<h4>Conclusions</h4>We report a case of anaphylaxis-induced uterine contractility in which uterine contractions subsided after the treatment of anaphylaxis. The absence of intra-amniotic infection and/or intra-amniotic inflammation and the cause of the anaphylaxis were confirmed. Our findings indicate that maternal allergic reactions may be one of the mechanisms of preterm labor.

Item Type:	Article
Uncontrolled Keywords:	Amniotic Fluid, Humans, Chorioamnionitis, Premature Birth, Anaphylaxis, Inflammation, Pregnancy, Labor, Obstetric, Uterine Contraction, Adult, Infant, Newborn, Female, Obstetric Labor, Premature
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	09 Apr 2024 08:39
Last Modified:	09 Apr 2024 13:18
DOI:	10.1186/s12884-024-06297-2
Open Access URL:	https://doi.org/10.1186/s12884-024-06297-2
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3180159