The importance of preclinical models in cholangiocarcinoma

McGreevy, Owen ORCID: 0000-0002-2029-0207, Bosakhar, Mohammed, Gilbert, Timothy ORCID: 0000-0003-4821-1897, Quinn, Marc, Fenwick, Stephen, Malik, Hassan, Goldring, Christopher and Randle, Laura ORCID: 0000-0002-7881-2979 (2024) The importance of preclinical models in cholangiocarcinoma. European Journal of Surgical Oncology. p. 108304.

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Official URL: http://dx.doi.org/10.1016/j.ejso.2024.108304

Abstract

Cholangiocarcinoma (CCA) is an adenocarcinoma of the hepatobiliary system with a grim prognosis. Incidence is rising globally and surgery is currently the only curative treatment, but is only available for patients who are fit and diagnosed in an early-stage of disease progression. Great importance has been placed on developing preclinical models to help further our understanding of CCA and potential treatments to improve therapeutic outcomes. Preclinical models of varying complexity and cost have been established, ranging from more simplistic in vitro 2D CCA cell lines in culture, to more complex in vivo genetically engineered mouse models. Currently there is no single model that faithfully recaptures the complexities of human CCA and the in vivo tumour microenvironment. Instead a multi-model approach should be used when designing preclinical trials to study CCA and potential therapies.

Item Type:	Article
Uncontrolled Keywords:	Cholangiocarcinoma, Human, Models, Pre-clinical
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	17 Apr 2024 10:45
Last Modified:	25 Apr 2024 22:29
DOI:	10.1016/j.ejso.2024.108304
Open Access URL:	https://doi.org/10.1016/j.ejso.2024.108304
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3180411