Ali, Ahmad MS 
ORCID: 0000-0001-9437-4262, Mustafa, Mohammad A, Ali, Omar ME, Gillespie, Conor S, Richardson, George M, Clark, Simon, Wilby, Martin J, Millward, Christopher P ORCID: 0000-0001-7727-1157 and Srikandarajah, Nisaharan
(2024)
Patient-reported outcomes in Primary Spinal Intradural Tumours: a systematic review.
Spinal cord.
pp. 1-10.
Abstract
<h4>Study design</h4>Systematic review.<h4>Objectives</h4>Primary Spinal Intradural Tumours (PSITs) are rare pathologies that can significantly impact quality of life. This study aimed to review patient reported outcomes (PROs) in PSITs.<h4>Methods</h4>A systematic search of Pubmed and Embase was performed to identify studies measuring PROs in adults with PSITs. PRO results were categorised as relating to Global, Physical, Social, or Mental health. Outcomes were summarised descriptively.<h4>Results</h4>Following review of 2382 records, 11 studies were eligible for inclusion (737 patients). All studies assessed surgically treated patients. Schwannoma was the commonest pathology (n = 190). 7 studies measured PROs before and after surgery, the remainder assessed only post-operatively. For eight studies, PROs were obtained within 12 months of treatment. 21 PRO measurement tools were used across included studies, of which Euro-Qol-5D (n = 8) and the pain visual/numerical analogue scale (n = 5) were utilised most frequently. Although overall QoL is lower than healthy controls in PSITs, improvements following surgery were found in Extramedullary tumours (EMT) in overall physical, social, and mental health. Similar improvements were not significant across studies of Intramedullary tumours (IMT). Overall QoL and symptom burden was higher in IMT patients than in brain tumour patients. No studies evaluated the effect of chemotherapy or radiotherapy.<h4>Conclusion</h4>Patients with PSITs suffer impaired PROs before and after surgery. This is particularly true for IMTs. PRO reporting in PSITs is hindered by a heterogeneity of reporting and varied measurement tools. This calls for the establishment of a standard set of PROs as well as the use of registries.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Rare Diseases, Neurosciences, Patient Safety, Cancer, 3 Good Health and Well Being |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Medicine Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 18 Apr 2024 09:54 |
| Last Modified: | 30 Apr 2024 10:41 |
| DOI: | 10.1038/s41393-024-00987-6 |
| Open Access URL: | https://doi.org/10.1038/s41393-024-00987-6 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3180422 |
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