Harris, Benjamin HL, Di Giovannantonio, Matteo, Zhang, Ping, Harris, David A, Lord, Simon R, Allen, Naomi E, Maughan, Tim S 
ORCID: 0000-0002-0580-5065, Bryant, Richard J, Harris, Adrian L, Bond, Gareth L et al (show 1 more authors)
(2024)
New role of fat-free mass in cancer risk linked with genetic predisposition.
Scientific reports, 14 (1).
p. 7270.
Abstract
Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 individuals. Using this dataset, a comprehensive analysis using regression, principal component and genome-wide genetic association, provided multiple levels of evidence that increasing whole body fat (WBFM) and fat-free mass (WBFFM) are both associated with increased post-menopausal breast cancer risk, and colorectal cancer risk in men. WBFM was inversely associated with prostate cancer. We also identified rs615029[T] and rs1485995[G] as associated in independent analyses with both PMBC (p = 1.56E-17 and 1.78E-11) and WBFFM (p = 2.88E-08 and 8.24E-12), highlighting splice variants of the intriguing long non-coding RNA CUPID1 (LINC01488) as a potential link between PMBC risk and fat-free mass.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Neoplasms, Genetic Predisposition to Disease, Body Mass Index, Body Composition, Electric Impedance, Male |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 23 Apr 2024 08:48 |
| Last Modified: | 23 Apr 2024 08:48 |
| DOI: | 10.1038/s41598-024-54291-7 |
| Open Access URL: | https://doi.org/10.1038/s41598-024-54291-7 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3180524 |
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