Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability

Pretorius, Etheresia, Akeredolu, Oore-Ofe, Soma, Prashilla and Kell, Douglas B ORCID: 0000-0001-5838-7963 (2017) Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability. EXPERIMENTAL BIOLOGY AND MEDICINE, 242 (4). pp. 355-373.

PDF
Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammati.pdf - Open Access published version
Download (1MB) | Preview

Official URL: http://dx.doi.org/10.1177/1535370216681549

Abstract

We review the evidence that infectious agents, including those that become dormant within the host, have a major role to play in much of the etiology of rheumatoid arthritis and the inflammation that is its hallmark. This occurs in particular because they can produce cross-reactive (auto-)antigens, as well as potent inflammagens such as lipopolysaccharide that can themselves catalyze further inflammagenesis, including via β-amyloid formation. A series of observables coexist in many chronic, inflammatory diseases as well as rheumatoid arthritis. They include iron dysregulation, hypercoagulability, anomalous morphologies of host erythrocytes, and microparticle formation. Iron dysregulation may be responsible for the periodic regrowth and resuscitation of the dormant bacteria, with concomitant inflammagen production. The present systems biology analysis benefits from the philosophical idea of "coherence," that reflects the principle that if a series of ostensibly unrelated findings are brought together into a self-consistent narrative, that narrative is thereby strengthened. As such, we provide a coherent and testable narrative for the major involvement of (often dormant) bacteria in rheumatoid arthritis.

Item Type:	Article
Uncontrolled Keywords:	Rheumatoid arthritis, dormancy, iron dysregulation, atopobiosis, infectious agents, lipopolysaccharides, Proteus, inflammation, comorbidities
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	30 Apr 2024 14:08
Last Modified:	30 Apr 2024 14:08
DOI:	10.1177/1535370216681549
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3180687