Pitfalls and procedures in the histopathological diagnosis of oral and oropharyngeal squamous cell carcinoma and a review of the role of pathology in prognosis.



Woolgar, Julia Anne and Triantafyllou, Asterios ORCID: 0000-0001-8752-5595
(2009) Pitfalls and procedures in the histopathological diagnosis of oral and oropharyngeal squamous cell carcinoma and a review of the role of pathology in prognosis. Oral oncology, 45 (4-5). pp. 361-385.

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Abstract

Histopathological assessment of formalin-fixed biopsy tissue and surgical resection specimens remains the cornerstone of cancer diagnosis and pathological staging in routine clinical practice. In recent years, standard protocols for reporting head and neck cancer have been widely used and these have improved the general level of the pathological assessment. In this article, we look beyond the standard protocols and deal with potential difficulties and pitfalls in the assessment of incisional biopsy specimens, surgical resection specimens and neck dissections. We draw attention to possible shortcomings and issues requiring clarification. Emphasis is given to precise histopathological definitions, histopathological detection and differential diagnosis. The approach is a practical one--a consideration of common experiences and dilemmas faced by the reporting pathologist, and where possible, we offer guidance and practical tips. The article concludes with a brief consideration of the prognostic value of accurate histopathological staging.

Item Type: Article
Additional Information: MATCHED FROM WOS Journal article Oral oncology Oral Oncol. 2008 Oct 10. ## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords: Mouth Mucosa, Humans, Carcinoma, Squamous Cell, Mouth Neoplasms, Oropharyngeal Neoplasms, Lymphatic Metastasis, Diagnosis, Differential, Biopsy, Sentinel Lymph Node Biopsy, Neoplasm Staging, Prognosis
Subjects: ?? RK ??
Divisions: Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Dentistry
Depositing User: Symplectic Admin
Date Deposited: 26 Nov 2008 12:18
Last Modified: 15 Mar 2024 13:27
DOI: 10.1016/j.oraloncology.2008.07.016
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/938