Moronkeji, Kikelomo, Todd, Simon, Dawidowska, Idalia and Akhtar, Riaz ORCID: 0000-0002-7963-6874
(2016)
Mechanics of Biological Systems and Materials, Volume 6.
In:
Mechanics of Biological Systems and Materials.
Conference Proceedings of the Society for Experimental Mechanics Series, 6
.
Springer International Publishing, pp. 39-49.
ISBN 9783319214542
This is the latest version of this item.
Text
15s_177_Moronkeji et al_impact testing of skin_final.pdf - Unspecified Access to this file is embargoed until Unspecified. Download (2MB) |
|
Atom XML (admin)
2017-05-13T07:48:11Z.atom - Unspecified Download (0B) |
|
Atom XML (admin)
2017-05-13T08:48:14Z.atom - Unspecified Download (0B) |
|
Atom XML (admin)
2017-05-13T09:47:05Z.atom - Unspecified Download (0B) |
Abstract
Microneedles provide a minimally invasive means of delivering drugs into the body via the skin. The challenge to effective microneedle penetration is to bypass the inherent elasticity of the stratum corneum, the skin’s uppermost layer. However, there are few studies in the literature which focus on optimising parameters for repeatable penetration into skin. Here, a dropped weight impact testing rig was developed to allow high-density polymethylmethacrylate (PMMA) microneedles to be applied on to neonatal porcine skin at various velocities and forces. Methylene blue and histological staining were used to determine penetration effectiveness. Whilst methylene blue staining confirmed successful penetration of the stratum corneum, subsequent histological imaging demonstrated how deeply the microneedles had breached the layers of skin. The optimal parameters of velocity and force for eproducible and predictable penetration of the skin were found to be 4.52–4.8 m/s (nominal velocity of 3 m/s) and 3.35–4.17 N.
Item Type: | Book Section |
---|---|
Subjects: | ?? Q1 ?? |
Depositing User: | Symplectic Admin |
Date Deposited: | 09 Sep 2015 10:47 |
Last Modified: | 17 Dec 2022 01:31 |
DOI: | 10.1007/978-3-319-21455-9 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/2025039 |
Available Versions of this Item
-
In Vitro Quantification of Optimal Impact Properties for Microneedle Penetration into Skin. (deposited 09 Sep 2015 09:43)
- Mechanics of Biological Systems and Materials, Volume 6. (deposited 09 Sep 2015 10:47) [Currently Displayed]