Growth Factor Release from Polyelectrolyte-Coated Titanium for Implant Applications

Peterson, Amy M, Pilz-Allen, Christine, Kolesnikova, Tatiana, Moehwald, Helmuth and Shchukin, Dmitry ORCID: 0000-0002-2936-804X (2014) Growth Factor Release from Polyelectrolyte-Coated Titanium for Implant Applications. ACS APPLIED MATERIALS & INTERFACES, 6 (3). pp. 1866-1871.

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Abstract

Polyelectrolyte multilayer coatings based on poly(methacrylic acid) and poly-l-histidine were formed on anodized titanium surfaces with adsorbed bone morphogenetic protein 2 (BMP-2) or basic fibroblast growth factor (FGFb). These coatings are proposed for use on titanium implanted devices. Coatings were capable of sustained release of growth factor over 25 days, with BMP-2 and FGFb exhibiting approximately identical release profiles. Cell culture on growth factor-eluting surfaces was more effective for preosteoblasts on BMP-2-eluting surfaces than for fibroblasts on FGFb-eluting surfaces. Cell counts at all time points on BMP-2-eluting surfaces were significantly higher than for those on anodized titanium or polyelectrolyte surfaces that did not contain BMP-2. Alkaline phosphatase levels were significantly higher after 21 days on BMP-2-eluting surfaces, indicating increased bone growth.

Item Type:	Article
Additional Information:	## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords:	polyelectrolytes, biomaterials, titanium implants, controlled release, bone morphogenetic protein 2, basic fibroblast growth factor
Subjects:	?? QD ??
Depositing User:	Symplectic Admin
Date Deposited:	11 Jan 2016 11:34
Last Modified:	15 Dec 2022 16:38
DOI:	10.1021/am404849y
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2045740

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• Growth Factor Release from Polyelectrolyte-Coated Titanium for Implant Applications. (deposited 11 Jan 2016 11:34) [Currently Displayed]