Susarrey-Arce, A, Sorzabal-Bellido, I ORCID: 0000-0001-8050-1443, Oknianska, A, McBride, F ORCID: 0000-0003-2985-3173, Beckett, AJ ORCID: 0000-0001-8377-325X, Gardeniers, JGE, Raval, R, Tiggelaar, RM and Fernandez, YA Diaz
(2016)
Bacterial viability on chemically modified silicon nanowire arrays.
JOURNAL OF MATERIALS CHEMISTRY B, 4 (18).
pp. 3104-3112.
Text
J Mat Chem B_repository.pdf - Author Accepted Manuscript Download (1MB) |
Abstract
The global threat of antimicrobial resistance is driving an urgent need for novel antimicrobial strategies. Functional surfaces are essential to prevent spreading of infection and reduce surface contamination. In this study we have fabricated and characterized multiscale-functional nanotopographies with three levels of functionalization: (1) nanostructure topography in the form of silicon nanowires, (2) covalent chemical modification with (3-aminopropyl)triethoxysilane, and (3) incorporation of chlorhexidine digluconate. Cell viability assays were carried out on two model microorganisms E. coli and S. aureus over these nanotopographic surfaces. Using SEM we have identified two growth modes producing distinctive multicellular structures, i.e. in plane growth for E. coli and out of plane growth for S. aureus. We have also shown that these chemically modified SiNWs arrays are effective in reducing the number of planktonic and surface-attached microorganisms.
Item Type: | Article |
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Uncontrolled Keywords: | Infectious Diseases, Emerging Infectious Diseases, Antimicrobial Resistance, Infection |
Depositing User: | Symplectic Admin |
Date Deposited: | 06 Sep 2016 11:03 |
Last Modified: | 11 Apr 2024 17:51 |
DOI: | 10.1039/c6tb00460a |
Open Access URL: | http://pubs.rsc.org/en/content/articlepdf/2016/tb/... |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3001063 |