Detecting Change in Conjunctival Hyperemia Using a Pixel Densitometry Index



Romano, Vito ORCID: 0000-0002-5148-7643, Steger, Bernhard, Brunner, Matthias, Kaye, Abigail, Zheng, Yalin ORCID: 0000-0002-7873-0922, Willoughby, Colin E and Kaye, Stephen B ORCID: 0000-0003-0390-0592
(2019) Detecting Change in Conjunctival Hyperemia Using a Pixel Densitometry Index. OCULAR IMMUNOLOGY AND INFLAMMATION, 27 (2). pp. 276-281.

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Abstract

<h4>Purpose</h4>To investigate a pixel densitometry index (PDI) for measuring ocular surface inflammation (OSI).<h4>Methods</h4>Efron's grading was performed by two independent observers. Color photographs and indocyanine green angiography were undertaken before and after instillation of phenylephrine (PE) hydrochloride 2.5%.<h4>Results</h4>A total of 15 patients with and 10 without OSI were included. PDI before and after PE was 73.29 ± 30.71 and 50.87 ± 17.46 (p = 0.036) in patients with inflammation and 52.86 ± 16.90 and 39.63 ± 12.04 (p = 0.0024) in those without OSI. The reduction in Efron grades following PE was 25% (mean 0.46 ± 0.50, median 0.50; p < 0.01). The coefficient of variation pre- and post-PE was lower using the PDI (42% and 50%) than with the Efron grades (59% and 72%).<h4>Conclusion</h4>The PDI allows the objective detection of change in conjunctival hyperemia with potential direct applicability to noninvasive angiography such as optical coherence tomography-based angiography.

Item Type: Article
Uncontrolled Keywords: Angiography, conjunctival inflammation, monitoring, pixel densitometry
Depositing User: Symplectic Admin
Date Deposited: 06 Oct 2017 10:00
Last Modified: 13 Feb 2024 15:36
DOI: 10.1080/09273948.2017.1387276
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3009802