Rational Design of Branched Au-Fe₃O₄ Janus Nanoparticles for Simultaneous Trimodal Imaging and Photothermal Therapy of Cancer Cells

Chen, Xiangjun, Li, Guilan, Han, Qinghe, Li, Xiliang, Li, Lu, Wang, Tingting and Wang, Chungang (2017) Rational Design of Branched Au-Fe₃O₄ Janus Nanoparticles for Simultaneous Trimodal Imaging and Photothermal Therapy of Cancer Cells. CHEMISTRY-A EUROPEAN JOURNAL, 23 (68). pp. 17204-17208.

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Abstract

We report a facile and simple hydrogen reduction method to fabricate PEGylated branched gold (Au)-iron oxide (Fe₃ O₄ ) Janus nanoparticles (JNPs). Note that the hydrogen induces the formation of Fe₃ O₄ during the synthesis process. Due to the strong absorption in the near-infrared range, branched Au-Fe₃ O₄ JNPs showed a significant photothermal effect with a 40 % calculated photothermal transduction efficiency under a laser irradiation of 808 nm in vitro. Owing to their excellent optical and magnetic properties, branched Au-Fe₃ O₄ JNPs were demonstrated to be advantageous agents for triple-modal magnetic resonance imaging (MRI)/photoacoustic imaging (PAI)/computed tomography (CT) in vitro. Therefore, the synthetic approach could be extended to prepare Au-metallic oxide JNPs for specific applications.

Item Type:	Article
Uncontrolled Keywords:	gold, Janus structures, nanoparticles, photothermal therapy, trimodal imaging
Depositing User:	Symplectic Admin
Date Deposited:	06 Nov 2017 11:33
Last Modified:	13 Oct 2023 15:06
DOI:	10.1002/chem.201704514
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3011425

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• Rational Design of Branched Au-Fe₃O₄ Janus Nanoparticles for Simultaneous Trimodal Imaging and Photothermal Therapy of Cancer Cells. (deposited 06 Nov 2017 11:33) [Currently Displayed]
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