Missing pieces of the puzzle to effectively control digital dermatitis

Orsel, K, Plummer, P, Shearer, J, De Buck, J, Carter, SD ORCID: 0000-0002-3585-9400, Guatteo, R and Barkema, HW (2018) Missing pieces of the puzzle to effectively control digital dermatitis. TRANSBOUNDARY AND EMERGING DISEASES, 65. pp. 186-198.

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Abstract

Since the first report of bovine digital dermatitis (DD) in 1974, there is a large body of the literature published; however, effective prevention and control of the disease remain elusive. Although many aspects of the pathogenesis of DD have been investigated, even some of the most basic questions such as the aetiology of this disease remain under debate. Treponema spp. have been strongly associated with DD lesions and occur in abundance in advanced lesions; however, efforts to induce disease with pure cultures of these organisms have been largely underwhelming and inconsistent. Furthermore, although the disease has been presented for several decades, there is limited scientific evidence regarding effective treatment of DD. Apparent discrepancies between effectiveness in vitro and in vivo have challenged the scientific community to identify new potential treatment options. With no treatment resulting in a 100% cure rate, the current expectation is manageable control, but prospects for the eradication of the disease are unlikely using current approaches. In order to develop more effective approaches to control DD on-farm, there is a critical need for a deeper understanding regarding the causation, ecology, transmission and treatment of this disease. In this article, we attempt to provide insights into specific research needs related to DD in order to assist the industry, researchers, pharmaceutical companies and research sponsors with decision-making and identified research gaps.

Item Type:	Article
Uncontrolled Keywords:	digital dermadidis, pathogenesis, transmission, veterinary epidemiology
Depositing User:	Symplectic Admin
Date Deposited:	17 Apr 2018 06:29
Last Modified:	20 Feb 2023 11:00
DOI:	10.1111/tbed.12729
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3020223