An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures



Collord, Grace, Tarpey, Patrick, Kurbatova, Natalja, Martincorena, Inigo, Moran, Sebastian, Castro, Manuel, Nagy, Tibor, Bignell, Graham, Maura, Francesco, Young, Matthew D
et al (show 29 more authors) (2018) An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures. SCIENTIFIC REPORTS, 8 (1). p. 95.

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Abstract

<jats:title>Abstract</jats:title><jats:p>Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal transition. Our analyses discern biologically distinct variants of anaplastic meningioma with prognostic and therapeutic significance.</jats:p>

Item Type: Article
Uncontrolled Keywords: Brain Disorders, Genetics, Human Genome, Cancer, Rare Diseases, Brain Cancer, 2 Aetiology, 2.1 Biological and endogenous factors, Aged, DNA Methylation, Disease Progression, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genomics, Humans, Male, Meningeal Neoplasms, Meningioma, Middle Aged, Neoplasm Grading, Neoplasm Recurrence, Local, Prognosis, Survival Analysis, Transcriptome, Whole Genome Sequencing
Depositing User: Symplectic Admin
Date Deposited: 10 Dec 2018 10:18
Last Modified: 15 Mar 2024 03:18
DOI: 10.1038/s41598-018-31659-0
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3029722