Non-tumour Bone Marrow Lymphocytes Correlate with Improved Overall Survival in Childhood Acute Lymphoblastic Leukaemia

Edwin, C, Dean, J, Bonnett, LJ ORCID: 0000-0002-6981-9212, Phillips, K ORCID: 0000-0002-6594-2635 and Keenan, R (2016) Non-tumour Bone Marrow Lymphocytes Correlate with Improved Overall Survival in Childhood Acute Lymphoblastic Leukaemia. Pediatric Blood and Cancer, 63 (10). pp. 1848-1851.

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Abstract

Composition of tumour immune cell infiltrates correlates with response to treatment and overall survival (OS) in several cancer settings. We retrospectively examined immune cells present in diagnostic bone marrow aspirates from paediatric patients with B‐cell acute lymphoblastic leukaemia. Our analysis identified a sub‐group (∼30% of patients) with >2.37% CD20 and >6.05% CD7 expression, which had 100% OS, and a sub‐group (∼30% of patients) with ≤2.37% CD20 and ≤6.05% CD7 expression at increased risk of treatment failure (66.7% OS, P < 0.05). Immune cell infiltrate at diagnosis may predict treatment response and could provide a means to enhance immediate treatment risk stratification.

Item Type:	Article
Uncontrolled Keywords:	acute lymphoblastic leukaemia, immunophenotype, lymphocyte, overall survival, paediatric cancer
Depositing User:	Symplectic Admin
Date Deposited:	04 Jan 2019 15:07
Last Modified:	19 Jan 2023 01:08
DOI:	10.1002/pbc.26093
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3030797

Available Versions of this Item

• Non-tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia. (deposited 17 May 2016 14:47)
  • Non-tumour Bone Marrow Lymphocytes Correlate with Improved Overall Survival in Childhood Acute Lymphoblastic Leukaemia. (deposited 04 Jan 2019 15:07) [Currently Displayed]