European evidence-based guidelines on pancreatic cystic neoplasms

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Del Chiaro, Marco, Besselink, Marc G, Scholten, Lianne, Bruno, Marco J, Cahen, Djuna L, Gress, Thomas M, van Hooft, Jeanin E, Lerch, Markus M, Mayerle, Julia, Hackert, Thilo et al (show 80 more authors) , Satoi, Sohei, Zerbi, Alessandro, Cunningham, David, De Angelis, Claudio, Giovanni, Marc, de-Madaria, Enrique, Hegyi, Peter, Rosendahl, Jonas, Friess, Helmut, Manfredi, Riccardo, Levy, Philippe, Real, Francisco X, Sauvanet, Alain, Abu Hilal, Mohammed, Marchegiani, Giovanni, Esposito, Irene, Ghaneh, Paula, Engelbrecht, Marc RW, Fockens, Paul, van Huijgevoort, Nadine CM, Wolfgang, Christopher, Bassi, Claudio, Gubergrits, Natalya B, Verbeke, Caroline, Kloppel, Gunter, Scarpa, Aldo, Zamboni, Giuseppe, Lennon, Anne Marie, Sund, Malin, Kartalis, Nikolaos, Grenacher, Lars, Falconi, Massimo, Arnelo, Urban, Kopchak, Kostantin V, Oppong, Kofi, McKay, Colin, Hauge, Truls, Conlon, Kevin, Adham, Mustapha, Ceyhan, Guralp O, Salvia, Roberto, Dervenis, Christos, Allen, Peter, Paye, Francois, Bartsch, Detlef K, Lohr, Matthias, Mutignani, Massimiliano, Laukkarinen, Johanna, Schulick, Richard, Valente, Roberto, Seufferlein, Thomas, Capurso, Gabriele, Siriwardena, Ajith, Neoptolemos, John P, Pukitis, Aldis, Segersvard, Ralf, Aghdassi, A, Andrianello, S, Bossuyt, P, Bulow, R, Cardenas-Jaen, K, Cortegoso, P, Fontana, M, Haeberle, L, Heckler, M, Litvin, A, Mann, K, Michalski, C, Michl, P, Nappo, G, Perri, G, Persson, S, Scheufele, F, Sclafani, F, Schmidt, M, Venezia, L, Volker, F, Vullierm, M-P, Wusten, L and Tum, European Study Grp Cystic (2018) European evidence-based guidelines on pancreatic cystic neoplasms. GUT, 67 (5). pp. 789-804.

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Abstract

Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology). Recommendations include conservative management, relative and absolute indications for surgery. A conservative approach is recommended for asymptomatic MCN and IPMN measuring <40 mm without an enhancing nodule. Relative indications for surgery in IPMN include a main pancreatic duct (MPD) diameter between 5 and 9.9 mm or a cyst diameter ≥40 mm. Absolute indications for surgery in IPMN, due to the high-risk of malignant transformation, include jaundice, an enhancing mural nodule >5 mm, and MPD diameter >10 mm. Lifelong follow-up of IPMN is recommended in patients who are fit for surgery. The European evidence-based guidelines on PCN aim to improve the diagnosis and management of PCN.

Item Type:	Article
Uncontrolled Keywords:	European Study Group on Cystic Tumours of the Pancreas, Pancreas, Humans, Pancreatic Cyst, Pancreatic Neoplasms, Europe, Practice Guidelines as Topic, Evidence-Based Practice
Depositing User:	Symplectic Admin
Date Deposited:	23 Jan 2019 15:50
Last Modified:	19 Jan 2023 01:06
DOI:	10.1136/gutjnl-2018-316027
Open Access URL:	https://gut.bmj.com/content/gutjnl/67/5/789.full.p...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3031692