Increased burden of comorbidities and risk of cardiovascular death in atrial fibrillation patients in Europe over ten years: A comparison between EORP-AF pilot and EHS-AF registries



Proietti, Marco ORCID: 0000-0003-1452-2478, Laroche, Cecile, Nieuwlaat, Robby, Crijns, Harry JGM, Maggioni, Aldo P, Lane, Deirdre A ORCID: 0000-0002-5604-9378, Boriani, Giuseppe and Lip, Gregory YH ORCID: 0000-0002-7566-1626
(2018) Increased burden of comorbidities and risk of cardiovascular death in atrial fibrillation patients in Europe over ten years: A comparison between EORP-AF pilot and EHS-AF registries. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 55. pp. 28-34.

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Abstract

<h4>Background</h4>In 2002, the European Society of Cardiology conducted the Euro Heart Survey (EHS), while in 2014concluded 1-year follow-up of the EURObservational Research Programme AF (EORP-AF) Pilot Registry.<h4>Methods</h4>We analysed differences in clinical profiles, therapeutic approaches and outcomes between these two cohorts after propensity score matching (PSM).<h4>Results</h4>After PSM, 5206 patients were analysed. In EORP-AF there were more elderly patients than EHS (p < .001). EORP-AF patients were more burdened with cardiovascular (CV) and non-CV comorbidities, with a higher proportion of patients with high thromboembolic risk. EORP-AF patients used more oral-anticoagulant (OAC) (p < .001). At 1-year follow-up EORP-AF patients had lower risk for thromboembolic and CV events, readmission for AF and other CV reasons (all p < .001), showing conversely a higher risk for CV death (p = .015). Kaplan-Meier curves showed that EORP-AF patients had higher risk for CV death (p < .0001) and all-cause death (p = .0019). Cox regression confirmed that EORP-AF patients were at higher risk for CV death (p = .021).<h4>Conclusions</h4>We found significant changes in AF epidemiology over a decade in Europe, with older patients, more burdened with comorbidities. A greater use of OAC was found. Despite a reduction in risk for thromboembolic events, a high risk of CV-related death was still evident.

Item Type: Article
Uncontrolled Keywords: Atrial fibrillation, Epidemiology, Europe, Thromboembolic risk, Mortality
Depositing User: Symplectic Admin
Date Deposited: 13 Aug 2019 09:13
Last Modified: 19 Jan 2023 00:35
DOI: 10.1016/j.ejim.2018.05.016
Open Access URL: http://pure-oai.bham.ac.uk/ws/files/48910032/Proie...
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3051216