Event-Related Desynchronization/Synchronization in Spinocerebellar Ataxia Type 3



Aoh, Yu, Hsiao, Han-Jun, Lu, Ming-Kuei, Macerollo, Antonella ORCID: 0000-0003-4322-2706, Huang, Hui-Chun, Hamada, Masashi, Tsai, Chon-Haw and Chen, Jui-Cheng
(2019) Event-Related Desynchronization/Synchronization in Spinocerebellar Ataxia Type 3. FRONTIERS IN NEUROLOGY, 10 (JUL). 822-.

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Abstract

<b>Introduction:</b> Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant, cerebellar degeneration predominant disease caused by excessive CAG repeats. We examined event-related dysynchronization/synchronization (ERD/ERS) in patients with SCA3. <b>Methods:</b> We assessed ERD/ERS of self-paced voluntary hand movements in 15 patients with genetically proven SCA3 in comparison with healthy controls. <b>Results:</b> In ERS, a significant interaction effect between group, frequency, and period (<i>F</i> = 1.591; <i>p</i> = 0.005; ρI = 0.86) was observed. The <i>post-hoc</i> two-tailed independent <i>t</i>-test showed significant differences in high beta and low beta ERS. By contrast, in ERD, no apparent differences were observed in the pattern of patients with SCA3 in comparison with healthy controls (<i>F</i> = 1.01; <i>p</i> = 0.442). <b>Conclusion:</b> The study revealed a decreased ERS in patients with SCA3, especially at the frequency of 20-30 Hz. This study elucidates the significant role of cerebellum in motor control.

Item Type: Article
Uncontrolled Keywords: ERD, ERS, cerebellar ataxia, SCA3, motor control
Depositing User: Symplectic Admin
Date Deposited: 12 Aug 2019 10:44
Last Modified: 19 Jan 2023 00:31
DOI: 10.3389/fneur.2019.00822
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3051469