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Number of items: 39.


Hong, W David, Benayoud, Farid, Nixon, Gemma L, Ford, Louise, Johnston, Kelly L, Clare, Rachel H, Cassidy, Andrew, Cook, Darren AN, Siu, Amy, Shiotani, Motohiro
et al (show 24 more authors) (2019) AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116 (4). pp. 1414-1419.


Johnston, Kelly L, Hong, W David, Turner, Joseph D, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Ward, Stephen A and Taylor, Mark J
(2021) Anti-Wolbachia drugs for filariasis. TRENDS IN PARASITOLOGY, 37 (12). pp. 1068-1081.


Secrieru, Alina, Costa, Ines CC, O'Neill, Paul M and Cristiano, Maria LS
(2020) Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis-A Short Bridge between Two Distant Illnesses. MOLECULES, 25 (7). E1574-.


Camarda, Grazia, Jirawatcharadech, Piyaporn, Priestley, Richard S, Saif, Ahmed, March, Sandra, Wong, Michael HL, Leung, Suet, Miller, Alex B, Baker, David A, Alano, Pietro
et al (show 5 more authors) (2019) Antimalarial activity of primaquine operates via a two-step biochemical relay. NATURE COMMUNICATIONS, 10 (1). 3226-.


Woodley, Christopher M, Amado, Patricia SM, Cristiano, Maria LS and O'Neill, Paul M ORCID: 0000-0003-4338-0317
(2021) Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies. MEDICINAL RESEARCH REVIEWS, 41 (6). pp. 3062-3095.


Ismail, Hanafy M, Barton, Victoria E, Panchana, Matthew, Charoensutthivarakul, Sitthivut, Biagini, Giancarlo A ORCID: 0000-0001-6356-6595, Ward, Stephen A and O'Neill, Paul M ORCID: 0000-0003-4338-0317
(2016) A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile. Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 128 (22). pp. 6511-6515.


Panmanee, Jiraporn, Bradley-Clarke, Jack, Mato, Jose M, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Antonyuk, Svetlana V ORCID: 0000-0002-2779-9946 and Hasnain, S Samar
(2019) Control and regulation of S‐Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone‐based compounds. The Federation of European Biochemical Societies (FEBS) Journal, 286 (11). pp. 2135-2154.


Wong, Michael HL, Bryan, Holly K, Copple, Ian M ORCID: 0000-0003-4101-1913, Jenkins, Rosalind E, Chiu, Pak Him, Bibby, Jaclyn, Berry, Neil G ORCID: 0000-0003-1928-0738, Kitteringham, Neil R, Goldring, Christopher E, O'Neill, Paul M ORCID: 0000-0003-4338-0317
et al (show 1 more authors) (2016) Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites. JOURNAL OF MEDICINAL CHEMISTRY, 59 (6). pp. 2396-2409.


Abdou, Moaz M, Dong, Dewen, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Amigues, Eric and Matziari, Magdalini
(2022) Design, Synthesis, and Study of a Novel RXPA380-Proline Hybrid (RXPA380-P) as an Antihypertensive Agent. ACS OMEGA, 7 (39). pp. 35035-35043.


Lisauskaitė, Monika ORCID: 0009-0000-1364-5439, Nixon, Gemma L ORCID: 0000-0002-9730-0960, Woodley, Christopher M ORCID: 0000-0003-1311-4288, Berry, Neil G ORCID: 0000-0003-1928-0738, Coninckx, Andy ORCID: 0000-0001-9821-2746, Qie, L Charlie ORCID: 0009-0002-6325-7447, Leung, Suet C, Taramelli, Donatella ORCID: 0000-0001-5108-4492, Basilico, Nicoletta ORCID: 0000-0001-9030-1066, Parapini, Silvia ORCID: 0000-0003-2079-8892
et al (show 5 more authors) (2024) Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>. RSC chemical biology, 5 (1). pp. 19-29.


Rajoli, Rajith KR ORCID: 0000-0002-6015-5712, Pertinez, Henry, Arshad, Usman ORCID: 0000-0003-1586-1885, Box, Helen, Tatham, Lee ORCID: 0000-0001-9448-8876, Curley, Paul ORCID: 0000-0003-4596-2708, Neary, Megan ORCID: 0000-0002-4960-2139, Sharp, Joanne, Liptrott, Neill J ORCID: 0000-0002-5980-8966, Valentijn, Anthony
et al (show 13 more authors) (2021) Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87 (4). pp. 2078-2088.


Rajoli, Rajith Kr ORCID: 0000-0002-6015-5712, Pertinez, Henry, Arshad, Usman ORCID: 0000-0003-1586-1885, Box, Helen, Tatham, Lee ORCID: 0000-0001-9448-8876, Curley, Paul ORCID: 0000-0003-4596-2708, Neary, Megan ORCID: 0000-0002-4960-2139, Sharp, Joanne, Liptrott, Neill J ORCID: 0000-0002-5980-8966, Valentijn, Anthony
et al (show 13 more authors) (2020) Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis. medRxiv : the preprint server for health sciences.


Chantadul, Varunya, Wright, Gareth SA ORCID: 0000-0002-3756-9634, Amporndanai, Kangsa, Shahid, Munazza, Antonyuk, Svetlana V ORCID: 0000-0002-2779-9946, Washbourn, Gina, Rogers, Michael, Roberts, Natalie, Pye, Matthew, O'Neill, Paul M ORCID: 0000-0003-4338-0317
et al (show 1 more authors) (2020) Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy. COMMUNICATIONS BIOLOGY, 3 (1). 97-.


Woodley, Christopher M, Nixon, Gemma L, Basilico, Nicoletta, Parapini, Silvia, Hong, Weiqian David, Ward, Stephen A, Biagini, Giancarlo A, Leung, Suet C, Taramelli, Donatella, Onuma, Keiko
et al (show 2 more authors) (2021) Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205. ACS MEDICINAL CHEMISTRY LETTERS, 12 (7). pp. 1077-1085.


Copple, Ian M ORCID: 0000-0003-4101-1913, Mercer, Amy E ORCID: 0000-0002-7399-8655, Firman, James, Donegan, Gail, Herpers, Bram, Wong, Michael HL, Chadwick, James, Bringela, Andreia D, Cristiano, Maria LS, van de Water, Bob
et al (show 3 more authors) (2012) Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials. MOLECULAR MEDICINE, 18 (7). pp. 1045-1055.


Johnston, Kelly L, Cook, Darren AN, Berry, Neil G ORCID: 0000-0003-1928-0738, Hong, W David, Clare, Rachel H, Goddard, Megan, Ford, Louise, Nixon, Gemma L, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Ward, Stephen A
et al (show 1 more authors) (2017) Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library. SCIENCE ADVANCES, 3 (09). eaao1551-.


Jeffreys, Laura N, Ardrey, Alison, Hafiz, Taghreed A, Dyer, Lauri-Anne, Warman, Ashley J, Mosallam, Nada, Nixon, Gemma L, Fisher, Nicholas E, Hong, W David, Leung, Suet C
et al (show 11 more authors) (2023) Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis. ACS INFECTIOUS DISEASES, 9 (2). pp. 221-238.


Clare, Rachel H, Bardelle, Catherine, Harper, Paul, Hong, W David, Borjesson, Ulf, Johnston, Kelly L, Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren
et al (show 21 more authors) (2019) Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides. NATURE COMMUNICATIONS, 10 (1). 11-.


Amporndanai, Kangsa, Meng, Xiaoli ORCID: 0000-0002-7774-2075, Shang, Weijuan, Jin, Zhenmig, Zhao, Yao, Rao, Zihe, Liu, Zhi-Jie, Yang, Haitao, Zhang, Leike, O'Neill, Paul M ORCID: 0000-0003-4338-0317
et al (show 2 more authors) (2021) Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. NATURE COMMUNICATIONS, 12 (1). 3061-.


Chu, Charmaine SM ORCID: 0000-0003-1051-2598, Simpson, Jack D, O'Neill, Paul M and Berry, Neil G ORCID: 0000-0003-1928-0738
(2021) Machine learning-Predicting Ames mutagenicity of small molecules. JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 109. 108011-.


Wong, Shi Quan, Pontifex, Matthew G, Phelan, Marie M, Pidathala, Chandra, Kraemer, Brian C, Barclay, Jeff W, Berry, Neil G ORCID: 0000-0003-1928-0738, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Burgoyne, Robert D ORCID: 0000-0002-9219-0387 and Morgan, Alan ORCID: 0000-0002-0346-1289
(2018) α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy. Neurobiology of disease, 118. pp. 40-54.


Thomson, Paul J ORCID: 0000-0001-5431-0459, Illing, Patricia T, Farrell, John ORCID: 0000-0002-8726-5997, Alhaidari, Mohammad, Bell, Catherine C, Berry, Neil ORCID: 0000-0003-1928-0738, O'Neill, Paul M, Purcell, Anthony W, Park, Kevin B and Naisbitt, Dean J
(2020) Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation. ALLERGY, 75 (3). pp. 636-647.


Amporndanai, Kangsa, Rogers, Michael, Watanabe, Seiji, Yamanaka, Koji, O'Neill, Paul M ORCID: 0000-0003-4338-0317 and Hasnain, S Samar
(2020) Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis. EBIOMEDICINE, 59. 102980-.


Horta, Pedro, Henriques, Marta SC, Bras, Elisa M, Murtinheira, Fernanda, Nogueira, Fatima, O'Neill, Paul M, Paixao, Jose A, Fausto, Rui and Cristiano, Maria LS
(2017) On the ordeal of quinolone preparation via cyclisation of aryl-enamines; synthesis and structure of ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3-carboxylate. PURE AND APPLIED CHEMISTRY, 89 (6). pp. 765-780.


Arshad, Usman ORCID: 0000-0003-1586-1885, Pertinez, Henry, Box, Helen, Tatham, Lee ORCID: 0000-0001-9448-8876, Rajoli, Rajith Kr ORCID: 0000-0002-6015-5712, Curley, Paul ORCID: 0000-0003-4596-2708, Neary, Megan ORCID: 0000-0002-4960-2139, Sharp, Joanne, Liptrott, Neill J ORCID: 0000-0002-5980-8966, Valentijn, Anthony
et al (show 12 more authors) (2020) Prioritisation of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics. Clinical pharmacology and therapeutics, 108 (4). pp. 775-790.


Amado, Patricia SM, Woodley, Christopher, Cristiano, Maria LS and O'Neill, Paul M ORCID: 0000-0003-4338-0317
(2022) Recent Advances of DprE1 Inhibitors against<i> Mycobacterium</i><i> tuberculosis:</i> Computational Analysis of Physicochemical and ADMET Properties. ACS OMEGA, 7 (45). pp. 40659-40681.


Jeffreys, Laura N, Pennington, Shaun H, Duggan, Jack, Caygill, Claire H, Lopeman, Rose C, Breen, Alastair F, Jinks, Jessica B, Ardrey, Alison, Donnellan, Samantha, Patterson, Edward I
et al (show 7 more authors) (2022) Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 59 (3). 106542-.


Stachulski, Andrew V, Santoro, M Gabriella, Piacentini, Sara, Belardo, Giuseppe, La Frazia, Simone, Pidathala, Chandrakala, Row, Eleanor C, Berry, Neil G ORCID: 0000-0003-1928-0738, Iqbal, Mazhar, Allman, Sarah A
et al (show 4 more authors) (2018) Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus. FUTURE MEDICINAL CHEMISTRY, 10 (8). pp. 851-862.


Lawrenson, Alexandre S, Cooper, David L ORCID: 0000-0003-0639-0794, O'Neill, Paul M ORCID: 0000-0003-4338-0317 and Berry, Neil G ORCID: 0000-0003-1928-0738
(2018) Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains. JOURNAL OF MOLECULAR MODELING, 24 (9). 237-.


Jiang, Zhengyun, Hong, W David, Cui, Xiping, Gao, Hongcan, Wu, Panpan, Chen, Yingshan, Shen, Ding, Yang, Yang, Zhang, Bingjie, Taylor, Mark J
et al (show 4 more authors) (2017) Synthesis and structure-activity relationship of <i>N</i><SUP>4</SUP>-benzylamine-<i>N</i><SUP>2</SUP>-isopropyl-quinazoline-2,4-diamines derivatives as potential antibacterial agents. RSC ADVANCES, 7 (82). pp. 52227-52237.


Rolt, Adam, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Liang, T Jake and Stachulski, Andrew V
(2019) Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR. RSC ADVANCES, 9 (69). pp. 40336-40339.


Stachulski, Andrew V, Rossignol, Jean-Francois, Pate, Sophie, Taujanskas, Joshua, Robertson, Craig M ORCID: 0000-0002-4789-7607, Aerts, Rudi, Pascal, Etienne, Piacentini, Sara, Frazia, Simone La, Santoro, M Gabriella
et al (show 1 more authors) (2021) Synthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts. FUTURE MEDICINAL CHEMISTRY, 13 (20). pp. 1731-1741.


Amporndanai, Kangsa, Pinthong, Nattapon ORCID: 0000-0002-0740-9496, O'Neill, Paul M, Hong, W David, Amewu, Richard K ORCID: 0000-0002-4676-436X, Pidathala, Chandrakala, Berry, Neil G ORCID: 0000-0003-1928-0738, Leung, Suet C, Ward, Stephen A, Biagini, Giancarlo A
et al (show 2 more authors) (2022) Targeting the Ubiquinol-Reduction (Q<sub>i</sub>) Site of the Mitochondrial Cytochrome <i>bc<sub>1</sub></i> Complex for the Development of Next Generation Quinolone Antimalarials. BIOLOGY-BASEL, 11 (8). 1109-.


Nixon, Gemma L ORCID: 0000-0002-9730-0960, Pidathala, Chandrakala, Shone, Alison E, Antoine, Thomas, Fisher, Nicholas, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Ward, Stephen A and Biagini, Giancarlo A
(2013) Targeting the mitochondrial electron transport chain of <i>Plasmodium falciparum</i>: new strategies towards the development of improved antimalarials for the elimination era. FUTURE MEDICINAL CHEMISTRY, 5 (13). pp. 1573-1591.


Stachulski, Andrew V ORCID: 0000-0002-5100-8884, Rossignol, Jean-Francois, Pate, Sophie, Taujanskas, Joshua, Iggo, Jonathan A ORCID: 0000-0001-8070-1226, Aerts, Rudi, Pascal, Etienne, Piacentini, Sara, La Frazia, Simone, Santoro, M Gabriella
et al (show 5 more authors) (2023) Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity. ACS bio & med chem Au, 3 (4). pp. 327-334.


Hong, W David, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Taylor, Mark J, Turner, Joseph D, Ward, Stephen A, Gusovsky, Fabian, Benayoud, Farid, Shibuguchi, Nao, Girish, Dixit, Fang, Francis Gerard
et al (show 9 more authors) (2023) Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 27 (1). pp. 42-53.


Abdou, Moaz M, O'Neill, Paul M, Amigues, Eric and Matziari, Magdalini
(2022) Unprecedented Convergent Synthesis of Sugar-Functionalization of Phosphinic Acids under Metal-Free Conditions. ACS OMEGA, 7 (25). pp. 21444-21453.


Wu, Pan-Pan, He, Hao, Hong, W David, Wu, Tong-Rong, Huang, Gui-Ying, Zhong, Ying-Ying, Tu, Bo-Rong, Gao, Min, Zhou, Jun, Zhao, Su-Qing
et al (show 6 more authors) (2018) The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents. INFECTION AND DRUG RESISTANCE, 11. pp. 1945-1957.


Capper, Michael J, Wright, Gareth SA ORCID: 0000-0002-3756-9634, Barbieri, Letizia, Luchinat, Enrico, Mercatelli, Eleonora, McAlary, Luke, Yerbury, Justin J, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Antonyuk, Svetlana V ORCID: 0000-0002-2779-9946, Banci, Lucia
et al (show 1 more authors) (2018) The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. NATURE COMMUNICATIONS, 9 (1). 1693-.

This list was generated on Mon Feb 5 08:16:49 2024 GMT.