The aetiology of hypodontia: the prevalence, severity and location of hypodontia within families.

Parkin, N, Elcock, C, Smith, RN, Griffin, RC and Brook, AH ORCID: 0000-0002-3484-3888
(2009) The aetiology of hypodontia: the prevalence, severity and location of hypodontia within families. Archives of oral biology, 54 Sup (Supple). S52-S56.

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<h4>Aims</h4>Previous studies have indicated that hypodontia has a significantly higher prevalence in the relatives of affected individuals than in the general population. This study aims to examine further the roles of genetic and environmental factors in the aetiology of hypodontia by investigating the relationship between the severity and distribution of hypodontia between family members, and any discernable effect of maternal health during pregnancy and birth weight.<h4>Methods and results</h4>117 first degree relatives of 41 index patients were examined clinically and radiographically to identify the presence, severity and location of hypodontia. Both siblings and parents of index patients had a higher prevalence of hypodontia than the general population. The number and location of missing teeth was not related to the number and location of missing teeth in parents or siblings. The expression of hypodontia within a family was not affected by maternal health during pregnancy.<h4>Conclusions</h4>The variation found in the expression of hypodontia within families suggests that its occurrence is not solely determined by genetic factors, but epigenetic and environmental factors probably also are important. This finding is consistent with a multifactorial aetiology for this condition.

Item Type: Article
Additional Information: Issue date: December 2009. Available online: 19 December 2008. Special supplement on International Workshop on Oral Growth and Development.
Uncontrolled Keywords: Humans, Anodontia, Genetic Predisposition to Disease, Radiography, Severity of Illness Index, Prevalence, Risk Factors, Statistics, Nonparametric, Environment, Epigenesis, Genetic, Pregnancy, Phenotype, Female, Male, United Kingdom
Subjects: ?? RK ??
Divisions: Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Dentistry
Depositing User: Symplectic Admin
Date Deposited: 20 Oct 2009 09:00
Last Modified: 16 Mar 2024 13:25
DOI: 10.1016/j.archoralbio.2008.11.002
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