Renal biomarkers in juvenile-onset systemic lupus erythematosus

Watson, Louise (2012) Renal biomarkers in juvenile-onset systemic lupus erythematosus Doctor of Philosophy thesis, University of Liverpool.

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Abstract

Background: Juvenile-onset Systemic Lupus Erythematosus (JSLE) is a rare, but severe, autoimmune condition with lupus nephritis (LN) occurring in up to 80% of patients and predisposing to an increased mortality. Aims/Objectives: As part of the UK JSLE Cohort Study this study aimed to identify whether standard and/or novel biomarkers are useful for monitoring LN and to assess whether novel urine biomarkers are released from the podocyte (kidney epithelial cell). Method/Results: A prospective translational study encompassing a clinical cross sectional biomarker analysis, a longitudinal observational biomarker study and scientific laboratory investigation. The study had full ethical approval. Cross sectional investigation identified whether (a) urine biomarkers (monocyte chemoattractant protein-1, MCP1; alpha-1-acid glycoprotein, AGP; interferon producing protein-10, IP10; neutrophil gelatinase associated lipocalin, NGAL) or (b) plasma biomarkers (interferon-gamma, IFN-γ; IP10; tumour necrosis factor alpha, TNF-α; interleukin 6, IL6; IL1β; MCP1; IL13; vascular endothelial growth factor, VEGF) are increased in JSLE patients with active renal disease. JSLE patients (n=60) and healthy controls (n=23) were recruited. ... (continues)

Item Type:	Thesis (Doctor of Philosophy)
Additional Information:	Date: 2012-11 (completed)
Divisions:	Faculty of Health & Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	04 Sep 2013 11:38
Last Modified:	18 Apr 2026 05:57
DOI:	10.17638/00010293
Supervisors:	Beresford, Michael ORCID: 0000-0002-5400-9911
URI:	https://livrepository.liverpool.ac.uk/id/eprint/10293
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