Multidrug-resistant tet(X)-containing hospital isolates in Sierra Leone.

Leski, Tomasz A ORCID: 0000-0001-7688-9887, Bangura, Umaru ORCID: 0000-0001-8789-3187, Jimmy, David Henry, Ansumana, Rashid ORCID: 0000-0002-1973-7200, Lizewski, Stephen E, Stenger, David A, Taitt, Chris Rowe ORCID: 0000-0002-0125-9239 and Vora, Gary J ORCID: 0000-0002-0657-8597 (2013) Multidrug-resistant tet(X)-containing hospital isolates in Sierra Leone. International journal of antimicrobial agents, 42 (1). pp. 83-86. ISSN 0924-8579, 1872-7913

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Abstract

The tet(X) gene encodes a flavin-dependent monooxygenase that confers resistance to all clinically relevant tetracycline antibiotics including tigecycline. It has only previously been identified in environmental and non-human pathogenic bacteria. To investigate levels of multidrug resistance in Bo, Sierra Leone, a molecular epidemiological study was conducted using an antimicrobial resistance determinant microarray (ARDM), PCR and DNA sequencing. The study found that 21% of isolates from Mercy Hospital (Bo, Sierra Leone) were tet(X)-positive, all of which originated from urinary specimens. Use of molecular epidemiological surveillance tools has provided the first evidence of tet(X)-containing multidrug-resistant Gram-negative hospital isolates in a hospital in Sierra Leone.

Item Type:	Article
Additional Information:	Available online 18 May 2013. Cite in press as: Leski TA, et al. Multidrug-resistant tet(X)-containing hospital isolates in Sierra Leone. Int J Antimicrob Agents (2013), http://dx.doi.org/10.1016/j.ijantimicag.2013.04.014 . Pages not for citation. 4 pages.
Uncontrolled Keywords:	Humans, Bacteria, Bacterial Infections, Tetracyclines, DNA, Bacterial, Anti-Bacterial Agents, Microarray Analysis, Polymerase Chain Reaction, Drug Resistance, Multiple, Bacterial, Genes, Bacterial, Hospitals, Sierra Leone, Molecular Epidemiology
Subjects:	?? RM ??
Divisions:	Faculty of Health & Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	29 May 2013 15:57
Last Modified:	07 Dec 2024 16:06
DOI:	10.1016/j.ijantimicag.2013.04.014
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/11535
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