Role of the redox responsive transcription factor, NRF2, in immune cell function

Hamdam, Junnat (2013) Role of the redox responsive transcription factor, NRF2, in immune cell function. Doctor of Philosophy thesis, University of Liverpool.

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Abstract

Dendritic cells (DCs) are potent innate antigen presenting cells which are able to sense and engulf pathogens from sites of infection, which are then processed and presented to adaptive T lymphocytes in secondary lymphoid organs. Therefore, they are critical for the initiation and modulation of primary antigen-specific adaptive immune responses. They also play a critical role in the maintenance of T cell tolerance. T cells play vital roles in mediating both cellular and humoral-specific adaptive immune responses. There are various types of T cells present within the immune system including the cytotoxic CD8 T cells and T helper CD4 cells. CD4 T cells can be further subdivided into various subtypes examples of which include T helper 1 cells (Th1), Th2, Th17 and T regulatory cells. Each subset has its own distinctive function, transcriptional regulation and effector cytokine profile. It is established that appropriate DC and T cell immune function is highly dependent on their intracellular redox status. Cellular redox homeostasis is maintained through a balance between oxidising agents e.g. reactive oxygen species (ROS) and anti-oxidant or reducing agents e.g. glutathione (GSH). Excessive ROS production resulting ... (continues)

Item Type:	Thesis (Doctor of Philosophy)
Additional Information:	Date: 2013-08 (completed)
Subjects:	?? RM ??
Divisions:	Faculty of Health and Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	11 Feb 2014 16:01
Last Modified:	03 Apr 2025 04:56
DOI:	10.17638/00014133
Supervisors:	Sathish, Jean Goldring, Christopher ORCID: 0000-0002-8951-2226
URI:	https://livrepository.liverpool.ac.uk/id/eprint/14133