Immunopathology of Complex Regional Pain Syndrome

Osborne, Scott
Immunopathology of Complex Regional Pain Syndrome. Doctor of Philosophy thesis, University of Liverpool.

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Both increased mast cells numbers and raised immune mediator concentrations indicate immune activation in the affected skin of patients with early CRPS, but little is known about regional immune cell involvement in late stage CRPS. The aim of the current study was to determine skin immune cell populations in longstanding CRPS. Using 6mm skin punch biopsies from CRPS-affected and non-affected tissues, and a combination of chemical and immunofluorescence staining, we examined the density and function of key cell populations including mast cells, epidermal Langerhans cells (LCs), and tissue resident T-cells. We found no significant differences in either overall immune cell infiltrates, or mast cell density between CRPS-affected and non-affected sub-epidermal tissue sections, contrasting recent findings in early CRPS by other groups. However, CD1a+ LC densities in the epidermal layer were significantly decreased in affected compared to non-affected CRPS limbs (p =

Item Type: Thesis (Doctor of Philosophy)
Additional Information: Date: 2013-05 (completed)
Subjects: ?? RC ??
Depositing User: Symplectic Admin
Date Deposited: 19 Feb 2014 12:25
Last Modified: 16 Dec 2022 04:40
DOI: 10.17638/00014485