Oxygen and pH-sensitivity of articular chondrocytes

Collins, John
Oxygen and pH-sensitivity of articular chondrocytes. Doctor of Philosophy thesis, University of Liverpool.

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Articular chondrocytes reside in a unique and challenging avascular environment in cartilage. During joint disease, O2 and pH levels are further reduced, and may be involved in chondrocyte dysfunction and cartilage matrix breakdown. How fluctuations in these environmental parameters affect factors such as redox balance and mitochondrial function in articular chondrocytes is largely unknown but may provide a link between the extracellular environment to cell signalling pathways that may alter cellular and hence cartilage integrity. Additionally, ROS-regulatory compounds may offer scope for therapeutic intervention in joint disease. In this project, the effects of different O2 levels (

Item Type: Thesis (Doctor of Philosophy)
Additional Information: Date: 2014-01 (completed)
Uncontrolled Keywords: cartilage, chondrocyte, mitochondrial dysfunction, oxidative stress, osteoarthritis
Subjects: ?? QP ??
Divisions: Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences > School of Veterinary Science
Depositing User: Symplectic Admin
Date Deposited: 06 Aug 2014 10:15
Last Modified: 16 Dec 2022 04:41
DOI: 10.17638/00015157
URI: https://livrepository.liverpool.ac.uk/id/eprint/15157