Mellor, Claire
(2014)
Developing safer HIV drugs : elucidating the mechanistic pathway of Tenofovir-induced cytotoxicity via mitochondrial dysfunction.
Doctor of Philosophy thesis, University of Liverpool.
PDF
MellorCla_2013_17093.pdf - Unspecified Access to this file is embargoed until Unspecified. After the embargo period this will be available under License Creative Commons Attribution No Derivatives. Download (4MB) |
|
PDF
MellorCla_Apr2014_17093.pdf - Author Accepted Manuscript Available under License Creative Commons Attribution No Derivatives. Download (4MB) |
Abstract
Human immune deficiency virus (HIV) currently affects around 34 million people worldwide, but due to recent advancements in antiretroviral treatments the morbidity and mortality of HIV has greatly improved (UNIAIDS, 2009). Tenofovir (TFV) is a nucleoside reverse transcriptase inhibitor (NRTI) that is currently widely used in most HIV regimens due to its favourable pharmacokinetic and pharmacodynamic properties, which allows for once daily dose (Gallent et al., 2004). TFV is used to treat HIV in both treatment experienced and treatment naive patients; it is also used as a treatment for hepatitis B and has recently been approved for use as a pre-exposure prophylaxis treatment. The preclinical trials for TFV showed that it had a good safety profile, however there has been an increasing number of patients presenting with TFV induced renal damage specifically proximal tubule dysfunction (Cooper et al., 2010). It was hypothesised that TFV was inducing this tubule damage via mitochondrial dysfunction, as this has been widely reported as an adverse reaction associated with NRTI’s (Kontorinis et al., 2003). Within these studies in vitro cell models were modified via culturing them in galactose media in order to probe ... (continues)
Item Type: | Thesis (Doctor of Philosophy) |
---|---|
Additional Information: | Date: 2014-04 (completed) |
Subjects: | ?? RM ?? |
Divisions: | Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
Depositing User: | Symplectic Admin |
Date Deposited: | 08 Aug 2014 10:51 |
Last Modified: | 02 Nov 2024 14:33 |
DOI: | 10.17638/00017093 |
Supervisors: |
|
URI: | https://livrepository.liverpool.ac.uk/id/eprint/17093 |