Chen, Chen
(2013)
Investigation of the MUC1-independent action of circulating galectins in metastasis promotion.
Doctor of Philosophy thesis, University of Liverpool.
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Abstract
Galectins are galactoside-binding proteins that are expressed by various types of human cells. Recent studies have shown that the levels of circulating galectins are significantly higher in the bloodstream of cancer patients and promote cancer cell adhesion and aggregation by interaction with the cancer-associated mucin protein MUC1. However, previous studies have also shown that circulating galectins have MUC1-independent actions in metastasis promotion. This thesis further explores these MUC-1 independent actions. The studies reported here show that galectin-2, 3, -4 and -8, whose serum concentrations are all increased in cancer patients, induce secretion of various cytokines from endothelial cells in vitro and in vivo: (G-CSF, GM-CSF, IL-6 and sICAM-1 by galectin-3; G-CSF, IL-6 and GROα/CXCL1 by galectin-2; G-CSF, IL-6, GROα/CXCL1 and MCP-1/CCL2 by galectin-4 and -8). The secretion of these cytokines autocrinely/paracrinely enhances the endothelial expression of cell surface adhesion molecules, causing adhesion of cancer cells to the blood vascular endothelium. The galectin-induced secretion of cytokines is also shown to promote endothelial cell migration and tubule formation in angiogenesis. Intravenous ... (continues)
| Item Type: | Thesis (Doctor of Philosophy) |
|---|---|
| Additional Information: | Date: 2013-09 (completed) |
| Subjects: | ?? QP ?? |
| Divisions: | Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 07 Aug 2014 11:20 |
| Last Modified: | 02 Nov 2024 14:31 |
| DOI: | 10.17638/00018533 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/18533 |
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