Characterisation of molecular mechanisms involved in nevirapine- induced hypersensitivity



Cornejo Castro, Elena Maria
(2014) Characterisation of molecular mechanisms involved in nevirapine- induced hypersensitivity. [Staff Thesis]

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Abstract

The non-nucleoside reverse transcriptase inhibitor nevirapine (NVP) is widely used in the treatment of human immunodeficiency virus infection in many sub- Saharan countries. However, NVP-treated individuals have a 5% risk of developing hypersensitivity reactions (HSRs), ranging from maculopapular exanthema to life-threatening severe cutaneous eruptions and hepatotoxicity. A number of clinical (gender and CD4+ T cell count) as well as immunogenetic factors (MHC class I and class II alleles) have been associated with NVP hypersensitivity, but the predictive value is poor. Gene expression analyses provide an unbiased method for determining which immune-related mechanisms are involved in the pathogenesis of NVP hypersensitivity. mRNA microarray analysis demonstrated that expression of CD177, a neutrophil specific antigen, was significantly increased in our cohort of NVP-treated patients from Malawi (p ≤ 0.001), but also after in vitro treatment of NVP-hypersensitive patients from Liverpool (p

Item Type: Staff Thesis
Additional Information: Date: 2014-03 (completed)
Subjects: ?? RM ??
Divisions: Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 19 Feb 2015 15:07
Last Modified: 26 Apr 2022 10:29
URI: https://livrepository.liverpool.ac.uk/id/eprint/19073