Ion Channels and Osteoarthritic Pain: Potential for Novel Analgesics

Staunton, CA ORCID: 0000-0003-0647-3063, Lewis, R and Barrett-Jolley, R ORCID: 0000-0003-0449-9972 (2013) Ion Channels and Osteoarthritic Pain: Potential for Novel Analgesics CURRENT PAIN AND HEADACHE REPORTS, 17 (12). 378-. ISSN 1531-3433, 1534-3081

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Abstract

Osteoarthritis (OA) is a debilitating chronic condition widely prevalent in ageing populations. Because the pathology of the disease includes cartilage erosion and joint remodelling, OA patients experience a great deal of pain. Despite numerous studies, details of OA are frequently inseparable from other types of chronic pain, and its causes are unknown. In most circumstances in OA, the cartilage lacks afferent innervation, although other joint tissues contain nociceptive neurones. In addition to physical joint damage, there is a strong element of joint inflammation. Genetic studies have identified several associations between ion channels and OA pain, including Na<inf>V</inf>1.7, P2X7, and TRPV1, but several other channels have also been implicated. Many ion channels involved with OA pain are common to those seen in inflammatory pain. This review considers causes of OA pain and discusses three possible pain-reducing strategies involving ion channel modulation: chondroprotection, innate afferent nerve inhibition, and inhibition of inflammatory hyperalgesia. Future targets for OA pain analgesia could involve a number of ion channels. © 2013 Springer Science+Business Media New York.

Item Type:	Article
Additional Information:	The final publication is available at Springer via http://dx.doi.org/10.1007/s11916-013-0378-z Date: 2013-11 (completed)
Uncontrolled Keywords:	Osteoarthritis, Chondrocytes, Cannabinoids, Ion channels, Dorsal root ganglia, Chronic pain, Gabapentin
Subjects:	?? QP ?? ?? RM ??
Divisions:	Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	15 Jul 2014 09:37
Last Modified:	16 Jun 2026 07:30
DOI:	10.1007/s11916-013-0378-z
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/19093
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