Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia


Qvist, Tavs, Gilljam, Marita, Jonsson, Bodil, Taylor-Robinson, David ORCID: 0000-0002-5828-7724, Jensen-Fangel, Soren, Wang, Mikala, Svahn, Anita, Kotz, Karsten, Hansson, Lennart, Hollsing, Annika et al (show 5 more authors) (2015) Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia JOURNAL OF CYSTIC FIBROSIS, 14 (1). pp. 46-52. ISSN 1569-1993, 1873-5010

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Abstract

Background: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described. Methods: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics. Results: During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p<. 0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died. Conclusion: NTM are significant CF pathogens and are becoming more prevalent in Scandinavia. MABSC and MAC appear to target distinct patient groups. Having multiple positive cultures despite treatment conveys a poor outcome.

Item Type: Article
Uncontrolled Keywords: Mycobacterium abscessus, Mycobacterium avium, Prevalence, Susceptibility
Depositing User: Symplectic Admin
Date Deposited: 05 Jan 2015 09:43
Last Modified: 16 Jun 2026 08:18
DOI: 10.1016/j.jcf.2014.08.002
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URI: https://livrepository.liverpool.ac.uk/id/eprint/2004246
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