Qvist, Tavs, Gilljam, Marita, Jonsson, Bodil, Taylor-Robinson, David ORCID: 0000-0002-5828-7724, Jensen-Fangel, Soren, Wang, Mikala, Svahn, Anita, Kotz, Karsten, Hansson, Lennart, Hollsing, Annika et al (show 5 more authors)
(2015)
Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia.
JOURNAL OF CYSTIC FIBROSIS, 14 (1).
pp. 46-52.
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Abstract
<h4>Background</h4>Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described.<h4>Methods</h4>In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics.<h4>Results</h4>During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p<0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died.<h4>Conclusion</h4>NTM are significant CF pathogens and are becoming more prevalent in Scandinavia. MABSC and MAC appear to target distinct patient groups. Having multiple positive cultures despite treatment conveys a poor outcome.
Item Type: | Article |
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Uncontrolled Keywords: | Mycobacterium abscessus, Mycobacterium avium, Prevalence, Susceptibility |
Depositing User: | Symplectic Admin |
Date Deposited: | 05 Jan 2015 09:43 |
Last Modified: | 16 Dec 2022 12:32 |
DOI: | 10.1016/j.jcf.2014.08.002 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/2004246 |