Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin.



Bolton, Jennifer L, Hayward, Caroline, Direk, Nese, Lewis, John G, Hammond, Geoffrey L, Hill, Lesley A, Anderson, Anna, Huffman, Jennifer, Wilson, James F, Campbell, Harry
et al (show 46 more authors) (2014) Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin. PLoS Genetics, 10 (7). e1004474 - ?.

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Abstract

Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 13 Jan 2015 09:12
Last Modified: 12 Nov 2019 13:59
URI: http://livrepository.liverpool.ac.uk/id/eprint/2004963
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