SVA retrotransposons as modulators of gene expression.



Quinn, John P and Bubb, Vivien J
(2014) SVA retrotransposons as modulators of gene expression. Mobile genetic elements, 4. e32102 - ?.

[img] Text
revised final mobile DNA elements commentary[1].pdf - Unspecified

Download (159kB)

Abstract

Endogenous mobile genetic elements can give rise to de novo germline or somatic mutations that can have dramatic consequences for genome regulation both local and possibly more globally based on the site of integration. However if we consider them as "normal genetic" components of the reference genome then they are likely to modify local chromatin structure which would have an effect on gene regulation irrelevant of their ability to further transpose. As such they can be treated as any other domain involved in a gene × environment interaction. Similarly their evolutionary appearance in the reference genome would supply a driver for species specific responses/traits. Our recent data would suggest the hominid specific subset of retrotransposons, SINE-VNTR-Alu (SVA), can function as transcriptional regulatory domains both in vivo and in vitro when analyzed in reporter gene constructs. Of particular interest in the SVA element, were the variable number tandem repeat (VNTR) domains which as their name suggests can be polymorphic. We and others have previously shown that VNTRs can be both differential regulators and biomarkers of disease based on the genotype of the repeat. Here, we provide an overview of why polymorphism in the SVA elements, in particular the VNTRs, could alter gene expression patterns that could be mechanistically associated with different traits in evolution or disease progression in humans.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 16 Jan 2015 15:51
Last Modified: 26 Apr 2022 10:33
DOI: 10.4161/mge.32102
URI: https://livrepository.liverpool.ac.uk/id/eprint/2005159