Cerebellar Abiotrophy in Two Related Lion-tailed Macaques (Macaca silenus)

Malbon, A, Ricci, E, Unwin, S and Chantrey, J
(2000) Cerebellar Abiotrophy in Two Related Lion-tailed Macaques (Macaca silenus).

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Cerebellar abiotrophy is a degenerative condition characterized by either early or late onset of severe neurological deficits caused by the marked depletion of Purkinje cells and granule cell neurons of the cerebellar cortex. The condition has been reported in numerous species with a proposed genetic basis of transmission. Here we present the anatomopathological investigation of two closely related lion-tailed macaques. Both cases, a 9-month-old male and a 4-month-old female, shared a long history of progressively worsening ataxia, incoordination and delayed body growth. Based on the characteristic findings, diagnoses of cerebellar abiotrophy were made. The relatedness of the two cases strongly supports an inherited mode of transmission. To the authors’ knowledge, this is the first report of cerebellar abiotrophy in a macaque species.

Item Type: Article
Subjects: R Medicine > RB Pathology
Depositing User: Symplectic Admin
Date Deposited: 16 Feb 2015 15:01
Last Modified: 07 Apr 2016 12:34
URI: http://livrepository.liverpool.ac.uk/id/eprint/2007005
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