Ehlers-Danlos Syndrome Associated with Fatal Spontaneous Vascular Rupture in a Dog

Uri, M, Verin, R ORCID: 0000-0001-9366-5682, Ressel, L ORCID: 0000-0002-6614-1223, Buckley, L and McEwan, N (2015) Ehlers-Danlos Syndrome Associated with Fatal Spontaneous Vascular Rupture in a Dog. JOURNAL OF COMPARATIVE PATHOLOGY, 152 (2-3). pp. 211-216.

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Abstract

A 7-month-old male cross breed dog was presented with hyperextensible skin and atrophic scarring. A diagnosis of Ehlers-Danlos syndrome was made based on clinical signs, histopathology and electron microscopy. Two weeks after presentation, the dog died suddenly. Post-mortem examination revealed haemothorax and rupture of the left subclavian artery. Histological findings, including Goldner's modified Masson's trichrome staining and transmission electron microscopy of the subclavian artery, revealed abnormalities in the structure and arrangement of collagen fibrils, suggesting that the defective collagen formation extended to the vasculature. To the authors' knowledge, this is the first report of Ehlers-Danlos syndrome with vascular involvement in animals.

Item Type:	Article
Uncontrolled Keywords:	defective collagen, dog, Ehlers-Danlos syndrome, vascular rupture
Depositing User:	Symplectic Admin
Date Deposited:	23 Feb 2015 10:19
Last Modified:	16 Dec 2022 12:20
DOI:	10.1016/j.jcpa.2014.12.013
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2007267