Fibronectin remodelling: cell-mediated regulation of the microenvironment

(2015) Fibronectin remodelling: cell-mediated regulation of the microenvironment. Biochemical Society Transactions, 43 (1). pp. 122-128. ISSN 0300-5127

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The biophysical, mechanical and chemical characteristics of extracellular matrixes influence many cellular functions to control tissue homoeostasis and drive progression of cancer and inflammatory diseases. To maintain normal tissue function, fibronectin-rich matrixes are subject to dynamic cell-mediated structural and chemical modification. In this article, we discuss how localized application of mechanical force, heterodimer-specific integrin engagement and matrix proteolysis regulate fibronectin assembly and turnover. We also speculate that recently identified integrin trafficking, syndecan signalling and adhesion receptor–growth factor receptor cross-talk mechanisms might dynamically control the function, assembly and mechanical properties of a viable, and mechanoresponsive, fibronectin network.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 24 Feb 2015 09:44
Last Modified: 31 Mar 2016 12:57

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