Urine D-arabinitol/L-arabinitol ratio in diagnosing <i>Candida</i> infection in patients with haematological malignancy and HIV infection


Eisen, DP, Bartley, PB, Hope, W ORCID: 0000-0001-6187-878X, Sigmundsdottir, G, Pehrson, C, Larsson, L and Christensson, B (2002) Urine D-arabinitol/L-arabinitol ratio in diagnosing <i>Candida</i> infection in patients with haematological malignancy and HIV infection. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 42 (1). pp. 39-42. ISSN 0732-8893, 1879-0070

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Abstract

Adult patients with hematologic malignancies along with HIV infected patients were prospectively studied to determine the performance of urine D-arabinitol/L-arabinitol (DA/LA) ratio in diagnosing invasive candidiasis. Ten evaluable febrile neutropenic patients had proven invasive candidiasis and elevated DA/LA ratios were found in 5. Invasive candidiasis with normal DA/LA ratios was most frequently due to Candida krusei infection. This Candida species is a non-producer of arabinitol. Only 4 of 81 febrile neutropenic patients given either antifungal prophylaxis or empiric antifungal treatment had elevated DA/LA ratios. Only 1 of 15 HIV positive patients with either oropharyngeal or esophageal candidiasis had elevated DA/LA ratios. Widespread use of fluconazole prophylaxis in bone marrow transplantation patients at the study hospital has led to an increased prevalence of C. krusei infection. This is the likely reason for the low sensitivity of the test in proven and suspected invasive Candida infections reported here.

Item Type: Article
Uncontrolled Keywords: Humans, Candida, AIDS-Related Opportunistic Infections, Candidiasis, Sugar Alcohols, Prospective Studies, Hematology, Adult
Subjects: ?? RB ??
?? RC ??
Depositing User: Symplectic Admin
Date Deposited: 24 Aug 2015 10:54
Last Modified: 07 Dec 2024 12:53
DOI: 10.1016/S0732-8893(01)00310-8
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/2007681
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