Bioinspired nanovalves with selective permeability and pH sensitivity



Zheng, Z ORCID: 0000-0001-6741-6148, Huang, X, Schenderlein, M, Moehwald, H, Xu, G-K and Shchukin, DG ORCID: 0000-0002-2936-804X
(2015) Bioinspired nanovalves with selective permeability and pH sensitivity. NANOSCALE, 7 (6). pp. 2409-2416.

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Abstract

Biological systems with controlled permeability and release functionality, which are among the successful examples of living beings to survive in evolution, have attracted intensive investigation and have been mimicked due to their broad spectrum of applications. We present in this work, for the first time, an example of nuclear pore complexes (NPCs)-inspired controlled release system that exhibits on-demand release of angstrom-sized molecules. We do so in a cost-effective way by stabilizing porous cobalt basic carbonates as nanovalves and realizing pH-sensitive release of entrapped subnano cargo. The proof-of-concept work also consists of the establishment of two mathematical models to explain the selective permeability of the nanovalves. Finally, gram-sized (or larger) quantities of the bio-inspired controlled release system can be synthesized through a scaling-up strategy, which opens up opportunities for controlled release of functional molecules in wider practical applications.

Item Type: Article
Subjects: ?? QD ??
Depositing User: Symplectic Admin
Date Deposited: 11 Jan 2016 11:24
Last Modified: 16 Dec 2022 12:04
DOI: 10.1039/c4nr06378c
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/2007993