ERP evidence suggests executive dysfunction in ecstasy polydrug users

Roberts, CA ORCID: 0000-0003-4275-601X, Fairclough, SH, Fisk, JE, Tames, F and Montgomery, C (2013) ERP evidence suggests executive dysfunction in ecstasy polydrug users. PSYCHOPHARMACOLOGY, 228 (3). pp. 375-388. ISSN 0033-3158, 1432-2072

	Text Roberts et al 2013 psychopharmacology ERP evidence suggests executive dysfunction in ecstasy polydrug users.pdf - Unspecified Access to this file is embargoed until Unspecified. Download (644kB)
	Text Roberts et al 2013 semantic.pdf - Unspecified Download (664kB)
	Text ERP evidence suggests executive dysfunction in ecstasy polydrug users.pdf - Unspecified Access to this file is embargoed until Unspecified. Download (437kB)

Abstract

<h4>Background</h4>Deficits in executive functions such as access to semantic/long-term memory have been shown in ecstasy users in previous research. Equally, there have been many reports of equivocal findings in this area. The current study sought to further investigate behavioural and electro-physiological measures of this executive function in ecstasy users.<h4>Method</h4>Twenty ecstasy-polydrug users, 20 non-ecstasy-polydrug users and 20 drug-naïve controls were recruited. Participants completed background questionnaires about their drug use, sleep quality, fluid intelligence and mood state. Each individual also completed a semantic retrieval task whilst 64 channel Electroencephalography (EEG) measures were recorded.<h4>Results</h4>Analysis of Variance (ANOVA) revealed no between-group differences in behavioural performance on the task. Mixed ANOVA on event-related potential (ERP) components P2, N2 and P3 revealed significant between-group differences in the N2 component. Subsequent exploratory univariate ANOVAs on the N2 component revealed marginally significant between-group differences, generally showing greater negativity at occipito-parietal electrodes in ecstasy users compared to drug-naïve controls. Despite absence of behavioural differences, differences in N2 magnitude are evidence of abnormal executive functioning in ecstasy-polydrug users.

Item Type:	Article
Uncontrolled Keywords:	Ecstasy, Cannabis, Executive function
Subjects:	?? BF ??
Depositing User:	Symplectic Admin
Date Deposited:	25 Mar 2015 15:24
Last Modified:	07 Dec 2024 14:07
DOI:	10.1007/s00213-013-3044-6
Publisher's Statement :	The final publication is available at Springer via http://dx.doi.org/10.1007/s00213-013-3044-6
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2008900