Tamarozzi, Francesca, Wright, Helen L ORCID: 0000-0003-0442-3134, Thomas, Huw B, Edwards, Steven W ORCID: 0000-0002-7074-0552 and Taylor, Mark J
(2014)
A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry.
IMMUNOLOGY LETTERS, 162 (2).
pp. 194-198.
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Abstract
We identified IL-17A-positive neutrophils in Wolbachia-positive Onchocerca volvulus nodules using an antibody that has previously reported IL-17A-positive neutrophils in several inflammatory conditions. However, we could not detect IL-17A using a range of alternative assays. Our data question the IL-17A antibody specificity and the ability of human neutrophils to express IL-17A.
Item Type: | Article |
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Uncontrolled Keywords: | Neutrophil, Interleukin-17, IL-17A, Wolbachia |
Depositing User: | Symplectic Admin |
Date Deposited: | 14 May 2015 09:42 |
Last Modified: | 16 Dec 2022 16:48 |
DOI: | 10.1016/j.imlet.2014.10.025 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/2011303 |
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