Genome-wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs

Baird, AEG, Carter, SD ORCID: 0000-0002-3585-9400, Innes, JF, Ollier, W and Short, A (2014) Genome-wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs. ANIMAL GENETICS, 45 (4). pp. 542-549. ISSN 0268-9146, 1365-2052

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Abstract

Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome-wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by Sequenom genotyping in a further cohort of Newfoundlands (n = 271). The results, particularly SNPs identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR.

Item Type:	Article
Uncontrolled Keywords:	cranial cruciate ligament rupture, Newfoundlands, population stratification
Depositing User:	Symplectic Admin
Date Deposited:	20 May 2015 09:51
Last Modified:	07 Dec 2024 09:14
DOI:	10.1111/age.12162
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2011537