Identification of novel anelloviruses with broad diversity in UK rodents

Nishiyama, S, Dutia, BM, Stewart, JP ORCID: 0000-0002-8928-2037, Meredith, AL, Shaw, DJ, Simmonds, P and Sharp, CP (2014) Identification of novel anelloviruses with broad diversity in UK rodents. Journal of General Virology, 95 (7). pp. 1544-1553.

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Abstract

Anelloviruses are a family of small circular ssDNA viruses with a vast genetic diversity. Human infections with the prototype anellovirus, torque teno virus (TTV), are ubiquitous and related viruses have been described in a number of other mammalian hosts. Despite over 15 years of investigation, there is still little known about the pathogenesis and possible disease associations of anellovirus infections, arising in part due to the lack of a robust cell culture system for viral replication or tractable small-animal model. We report the identification of diverse anelloviruses in several species of wild rodents. The viruses are highly prevalent in wood mice (Apodemus sylvaticus) and field voles (Microtus agrestis), detectable at a low frequency in bank voles (Myodes glareolus), but absent from house mice (Mus musculus). The viruses identified have a genomic organization consistent with other anelloviruses, but form two clear phylogenetic groups that are as distinct from each other as from defined genera.

Item Type:	Article
Uncontrolled Keywords:	Animals, Mice, DNA Virus Infections, Cluster Analysis, Sequence Analysis, DNA, Phylogeny, Molecular Sequence Data, Arvicolinae, Murinae, Genetic Variation, Anelloviridae, United Kingdom
Subjects:	?? QR355 ??
Depositing User:	Symplectic Admin
Date Deposited:	04 Feb 2016 10:28
Last Modified:	23 Feb 2023 05:16
DOI:	10.1099/vir.0.065219-0
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2016397