Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding

Zacharchenko, Thomas, von Castelmur, Eleonore, Rigden, Daniel J ORCID: 0000-0002-7565-8937 and Mayans, Olga (2015) Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding. BIOCHEMICAL SOCIETY TRANSACTIONS, 43 (5). pp. 850-855.

	Text bst20150084_submitted.pdf - Author Accepted Manuscript Download (667kB)
	Text bst2015-0084a.pdf - Unspecified Access to this file is embargoed until Unspecified. Download (1MB)

Official URL: http://dx.doi.org/10.1042/bst20150084

Abstract

Titin is a gigantic filamentous protein of the muscle sarcomere that plays roles in myofibril mechanics and homoeostasis. 3D-structures of multi-domain fragments of titin are now available that start revealing the molecular mechanisms governing its mechanical and scaffolding functions. This knowledge is now being translated into the fabrication of self-assembling biopolymers. Here we review the structural advances on titin, the novel concepts derived from these and the emerging translational avenues.

Item Type:	Article
Uncontrolled Keywords:	crystal structure, multi-Ig tandem, protein nanofibre, protein scaffold, titin
Depositing User:	Symplectic Admin
Date Deposited:	30 Jul 2015 15:02
Last Modified:	15 Dec 2022 12:18
DOI:	10.1042/BST20150084
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2018483