The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol (vol 119, pg 97, 2015)


Hickey, Graeme L ORCID: 0000-0002-4989-0054, Diggle, Peter J, McNeilly, Tom N, Tongue, Sue C, Chase-Topping, Margo E and Williams, Diana JL ORCID: 0000-0001-8186-7236 (2015) The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol (vol 119, pg 97, 2015). [Poster]

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Abstract

Background: The parasite Fasciola hepatica is a major cause of economic loss to the agricultural community worldwide as a result of morbidity and mortality in livestock, including cattle. Cattle are the principle reservoir of Verocytotoxigenic Escherichia coli O157 (VTEC O157), an important cause of disease in humans. To date there has been little empirical research on the interaction between F. hepatica and VTEC O157. It is hypothesised that F. hepatica, which is known to suppress type 1 immune responses and induce an anti-inflammatory or regulatory immune environment in the host, may promote colonisation of the bovine intestine with VTEC O157. Objectives: Here we assess whether it is statistically feasible to augment a prospective study to quantify the prevalence of VTEC O157 in cattle in Great Britain with a pilot study to test this hypothesis. Methods: We simulate data that conforms to known individual-level and farm-level prevalence on average under a mixed-effects logistic regression model framework. We use Monte Carlo sampling to empirically calculate the power to detect an association effect size (odds ratio) of 2. In order to reduce the resources required for such a study, we exploit the fact that the test results for VTEC O157 will be known in advance of testing for F. hepatica by restricting analysis to farms with a VTEC O157 sample prevalence of >0% and

Item Type: Poster
Depositing User: Symplectic Admin
Date Deposited: 01 Sep 2015 08:31
Last Modified: 16 Dec 2022 12:23
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/2023464
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