An in situ study to determine the effects of casein phosphopeptide-amorphous calcium phosphate toothpaste in orthodontic patients



Garry, Andrew
An in situ study to determine the effects of casein phosphopeptide-amorphous calcium phosphate toothpaste in orthodontic patients. Doctor of Dental Science thesis, University of Liverpool.

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Abstract

Objectives: To investigate the remineralisation of enamel subsurface lesions with CPP-ACP toothpaste compared with regular fluoride toothpaste in orthodontic patients. Design: Randomised controlled clinical trial with a cross-over design. Setting: Orthodontic department at the Liverpool University Dental Hospital. Participants: 12 orthodontic patients receiving fixed orthodontic treatment. Methods: Demineralised sub-surface enamel lesions were placed in situ onto a fixed appliance in the lower premolar region. Participants were randomly allocated to receive either standard fluoride toothpaste or a CPP-ACP paste (GC Tooth Mousse™) in addition to the fluoride toothpaste. Transverse Microradiography (TMR) was used to analyse and compare the mineral content profiles of the lesions. Results: Mineral loss ΔZ reduced by 15.4% and 24.6% for the fluoride and CPP-ACP groups respectively, with a statistical significant difference between these groups (p = 0.023). Lesion depth reduced by 1.6% and 11.1% for fluoride and CPP-ACP groups respectively, with a statistically significant difference between these groups (p = 0.037). Lesion width reduced by 4.5% and 15.3% for fluoride and CPP-ACP groups respectively, with a statistically significant difference between these groups (p=0.015). Conclusion/Implications: Remineralisation occurred during the in situ phase regardless of treatment group allocation, however the CPP-ACP combined with fluoride group demonstrated a statistically significant increased remineralising effect. CPP-ACP paste may be beneficial for patients undergoing orthodontic treatment who are at high risk of demineralisation or who have demonstrated early signs of white spot lesion formation. Trial Registration: Registered on Current Control Trials http://www.controlled-trials.com/ISRCTN04899524

Item Type: Thesis (Doctor of Dental Science)
Additional Information: Date: 2015-10-29 (completed)
Subjects: ?? RK ??
Depositing User: Symplectic Admin
Date Deposited: 21 Jan 2016 14:21
Last Modified: 19 Sep 2022 11:09
DOI: 10.17638/02034461
URI: https://livrepository.liverpool.ac.uk/id/eprint/2034461