Genetic and metabolic predictors of chemosensitivity in oligodendroglial neoplasms

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Walker, C, Haylock, B, Husband, D, Joyce, KA, Fildes, D, Jenkinson, MD ORCID: 0000-0003-4587-2139, Smith, T, Broome, J, Kopitzki, K, du Plessis, DG et al (show 3 more authors) , Prosser, J, Vinjamuri, S and Warnke, PC (2006) Genetic and metabolic predictors of chemosensitivity in oligodendroglial neoplasms BRITISH JOURNAL OF CANCER, 95 (10). pp. 1424-1431. ISSN 0007-0920, 1532-1827

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Abstract

The -1p/-19q genotype predicts chemosensitivity in oligodendroglial neoplasms, but some with intact 1p/19q also respond and not all with 1p/19q loss derive durable benefit from chemotherapy. We have evaluated the predictive and prognostic significance of pretherapy ²⁰¹Tl and ¹⁸F-FDG SPECT and genotype in 38 primary and 10 recurrent oligodendroglial neoplasms following PCV chemotherapy. 1p/19q loss was seen in 8/15 OII, 6/15 OAII, 7/7 OIII, 3/11 OAIII and was associated with response (Fisher-Exact: P = 0.000) and prolonged progression-free (log-rank: P = 0.002) and overall survival (OS) (log-rank: P = 0.0048). Response was unrelated to metabolism, with tumours with high or low metabolism showing response. Increased ¹⁸F-FDG or ²⁰¹Tl uptake predicted shorter progression-free survival (PFS) in the series (log-rank: ²⁰¹Tl P = 0.0097, ¹⁸F-FDG P = 0.0170) and in cases with or without the -1p/-19q genotype. Elevated metabolism was associated with shorter OS in cases with intact 1p/19q (log-rank: ¹⁸FFDG P = 0.0077; ²⁰¹Tl P = 0.0004) and shorter PFS in responders (log-rank: ¹⁸F-FDG P = 0.005; ²⁰¹Tl P = 0.0132). ²⁰¹Tl uptake and 1p/19q loss were independent predictors of survival in multivariate analysis. In this initial study, ²⁰¹Tl and ¹⁸F-FDG uptake did not predict response to PCV, but may be associated with poor survival following therapy irrespective of genotype. This may be clinically useful warranting further study. © 2006 Cancer Research UK.

Item Type:	Article
Uncontrolled Keywords:	oligodendroglioma, (201)Thallium SPECT, (18)Fluorodeoxyglucose SPECT, 1p/19q loss, chemosensitivity
Depositing User:	Symplectic Admin
Date Deposited:	23 Nov 2015 09:23
Last Modified:	16 Jun 2026 03:57
DOI:	10.1038/sj.bjc.6603390
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2038346
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