Human and mouse enteric nervous system neurosphere transplants regulate the function of aganglionic embryonic distal colon.



Lindley, Richard, Hawcutt, Dan ORCID: 0000-0002-8120-6507, Connell, Gwen, Almond, Sarah, Vannucchi, Maria-Giuliana, Faussone-Pellegrini, Maria Simonetta, Edgar, David and Kenny, Simon
(2008) Human and mouse enteric nervous system neurosphere transplants regulate the function of aganglionic embryonic distal colon. Gastroenterology, 135 (1). 205 - 216.

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Abstract

Neonatal human gut is a source of ENSPC that can be transplanted to restore the contractile properties of aganglionic bowel by a neurally mediated mechanism. This may aid development of a stem cell-based treatment for Hirschsprung's disease.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 13 Jan 2016 10:41
Last Modified: 02 Apr 2021 07:11
URI: https://livrepository.liverpool.ac.uk/id/eprint/2042320