Pharmacodynamic Modeling of Bacillary Elimination Rates and Detection of Bacterial Lipid Bodies in Sputum to Predict and Understand Outcomes in Treatment of Pulmonary Tuberculosis



Sloan, Derek, Mwandumba, Henry, Garton, Natalie J, Khoo, Saye, Butterworth, Anthony E, Allain, Theresa J, Heyderman, Robert S, Corbett, Elizabeth L, Barer, Mike R and Davies, Geraint
(2015) Pharmacodynamic Modeling of Bacillary Elimination Rates and Detection of Bacterial Lipid Bodies in Sputum to Predict and Understand Outcomes in Treatment of Pulmonary Tuberculosis. Clinical Infectious Diseases, 61 (01). 1 - 8.

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Abstract

Modeling BERs predicts final outcome, and high %LB + AFB counts 3-4 weeks into therapy may identify a persister bacterial phenotype. These methods deserve further evaluation as surrogate endpoints for clinical trials.

Item Type: Article
Additional Information: Derek J. Sloan, Henry C. Mwandumba, Natalie J. Garton, Saye H. Khoo, Anthony E. Butterworth, Theresa J. Allain, Robert S. Heyderman, Elizabeth L. Corbett, Mike R. Barer, and Geraint R. Davies Pharmacodynamic Modeling of Bacillary Elimination Rates and Detection of Bacterial Lipid Bodies in Sputum to Predict and Understand Outcomes in Treatment of Pulmonary Tuberculosis Clin Infect Dis. (2015) 61 (1): 1-8 first published online March 16, 2015 doi:10.1093/cid/civ195
Uncontrolled Keywords: tuberculosis, sterilizing activity, persistence, lipid bodies, clinical trials
Subjects: R Medicine > RM Therapeutics. Pharmacology
Depositing User: Symplectic Admin
Date Deposited: 07 Jan 2016 15:27
Last Modified: 06 May 2020 17:13
DOI: 10.1093/cid/civ195
Publisher's Statement : © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Societyof America. This is an Open Access article distributed undertheterms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited
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URI: http://livrepository.liverpool.ac.uk/id/eprint/2044920