Mzinza, David T, Sloan, Derek J, Jambo, Kondwani C 
ORCID: 0000-0002-3195-2210, Shani, Doris, Kamdolozi, Mercy, Wilkinson, Katalin A, Wilkinson, Robert J, Davies, Geraint R ORCID: 0000-0002-3819-490X, Heyderman, Robert S and Mwandumba, Henry C
(2015)
Kinetics of Mycobacterium tuberculosis-specific IFN-gamma responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis.
TUBERCULOSIS, 95 (4).
pp. 463-469.
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Abstract
In HIV-uninfected adults with pulmonary tuberculosis (TB), anti-TB treatment is associated with changes in Mycobacterium tuberculosis (Mtb)-specific immune responses, which correlate with sputum bacillary load. It is unclear if this occurs in HIV-infected TB patients. We investigated changes in Mtb-specific immune responses and sputum bacillary clearance during anti-TB treatment in HIV-infected and HIV-uninfected adults with pulmonary TB. Sputum bacillary load was assessed by smear microscopy and culture. Mtb-specific IFN-γ secreting peripheral blood mononuclear cells were enumerated using an ELISPOT assay following stimulation with PPD, ESAT-6 and CFP-10. The baseline frequency of Mtb-specific IFN-γ secreting cells was lower in HIV-infected than HIV-uninfected patients (median PPD 32 vs. 104 Spot Forming Units (SFU), p = 0.05; CFP-10 19 vs. 74 SFU, p = 0.01). ESAT-6-specific IFN-γ secreting cells and sputum bacillary load declined progressively during treatment in both HIV-infected and HIV-uninfected patients. HIV infection did not influence the 2-month sputum culture conversion rate (Odds Ratio 0.89, p = 0.95). These findings suggest that changes in ESAT-6-specific immune responses during anti-TB treatment correspond with changes in sputum bacillary load irrespective of host HIV infection status. The utility of Mtb-specific IFN-γ responses as a proxy measure of treatment response in HIV-infected TB patients warrants further evaluation in other settings.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Mycobacterium tuberculosis, Antigen-specific immunity, IFN-gamma, Pulmonary tuberculosis, HIV infection, Anti-tuberculosis treatment |
| Subjects: | ?? R1 ?? |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 08 Jan 2016 16:57 |
| Last Modified: | 15 Dec 2022 12:18 |
| DOI: | 10.1016/j.tube.2015.05.009 |
| Publisher's Statement : | © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/2045400 |
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