Ecological assessment of the direct and indirect effects of routine rotavirus vaccination in Merseyside, UK using data from multiple health systems: a study protocol



Hungerford, Daniel ORCID: 0000-0002-9770-0163, Vivancos, Roberto, French, Neil ORCID: 0000-0003-4814-8293, Iturriza-Gomara, Miren ORCID: 0000-0001-5816-6423 and Cunliffe, Nigel ORCID: 0000-0002-5449-4988
(2014) Ecological assessment of the direct and indirect effects of routine rotavirus vaccination in Merseyside, UK using data from multiple health systems: a study protocol. BMJ OPEN, 4 (11). e006161-.

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Abstract

<h4>Introduction</h4>Rotavirus is the most common cause of severe gastroenteritis in infants and young children worldwide. Currently 67 countries include rotavirus vaccine in childhood immunisation programmes, but uptake in Western Europe has been slow. In July 2013, rotavirus vaccine was introduced into the UK's routine childhood immunisation programme. Prior to vaccine introduction in the UK, rotavirus was estimated to result in 750,000 diarrhoea episodes and 80,000 general practice (GP) consultations each year, together with 45% and 20% of hospital admissions and emergency department attendances for acute gastroenteritis, in children under 5 years of age. This paper describes a protocol for an ecological study that will assess rotavirus vaccine impact in the UK, to inform rotavirus immunisation policy in the UK and in other Western European countries.<h4>Methods and analysis</h4>In Merseyside, UK, we will conduct an ecological study using a 'before and after' approach to examine changes in gastroenteritis and rotavirus incidence following the introduction of rotavirus vaccination. Data will be collected on mortality, hospital admissions, nosocomial infection, emergency department attendances, GP consultations and community health consultations to capture all healthcare providers in the region. We will assess both the direct and indirect effects of the vaccine on the study population. Comparisons of outcome indicator rates will be made in relation to vaccine uptake and socioeconomic status.<h4>Ethics and dissemination</h4>The study has been approved by NHS Research Ethics Committee, South Central-Berkshire REC Reference: 14/SC/1140. Study outputs will be disseminated through scientific conferences and peer-reviewed publications. The study will demonstrate the impact of rotavirus vaccination on the burden of disease from a complete health system perspective. It will identify key areas that require improved data collection tools to maximise the usefulness of this surveillance approach and will provide a template for vaccine evaluations using ecological methods in the UK.

Item Type: Article
Additional Information: Cite as: Hungerford D, Vivancos R, French N, et al. Ecological assessment of the direct and indirect effects of routine rotavirus vaccination in Merseyside, UK using data from multiple health systems: a study protocol. BMJ Open 2014;4:e006161. doi:10.1136/bmjopen-2014- 006161
Uncontrolled Keywords: Humans, Rotavirus Infections, Gastroenteritis, Rotavirus Vaccines, Child, Preschool, Infant, National Health Programs, United Kingdom
Depositing User: Symplectic Admin
Date Deposited: 12 Jan 2016 17:15
Last Modified: 20 May 2024 11:19
DOI: 10.1136/bmjopen-2014-006161
Publisher's Statement : This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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URI: https://livrepository.liverpool.ac.uk/id/eprint/2046360