Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide



Truran, Seth, Weissig, Volkmar, Madine, Jillian ORCID: 0000-0001-9963-5871, Davies, Hannah A, Guzman-Villanueva, Diana, Franco, Daniel A, Karamanova, Nina, Burciu, Camelia, Serrano, Geidy, Beach, Thomas G
et al (show 1 more authors) (2016) Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36 (2). pp. 405-412.

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Abstract

We tested whether nanoliposomes containing phosphatidylcholine, cholesterol and phosphatidic acid (NLPA) prevent β-amyloid 1-42 (Aβ42) fibrillation and Aβ42-induced human arteriole endothelial dysfunction. NLPA abolished Aβ42 fibril formation (thioflavin-T fluorescence/electron microscopy). In ex-vivo human adipose and leptomeningeal arterioles, Aβ42 impaired dilator response to acetylcholine that was reversed by NLPA; this protection was abolished by L-NG-nitroarginine methyl ester. Aβ42 reduced human umbilical vein endothelial cell NO production that was restored by NLPA. Nanoliposomes prevented Aβ42 amyloid formation, reversed Aβ42-induced human microvascular endothelial dysfunction and may be useful in Alzheimer's disease.

Item Type: Article
Uncontrolled Keywords: Amyloid, Alzheimer's disease, endothelial function, liposome, microvasculature
Depositing User: Symplectic Admin
Date Deposited: 20 Jan 2016 15:47
Last Modified: 05 Oct 2023 09:26
DOI: 10.1177/0271678X15610134
Open Access URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC47596...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/2047663

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