Truran, Seth, Weissig, Volkmar, Madine, Jillian 
ORCID: 0000-0001-9963-5871, Davies, Hannah A, Guzman-Villanueva, Diana, Franco, Daniel A, Karamanova, Nina, Burciu, Camelia, Serrano, Geidy, Beach, Thomas G et al (show 1 more authors)
(2016)
Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36 (2).
pp. 405-412.
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Abstract
We tested whether nanoliposomes containing phosphatidylcholine, cholesterol and phosphatidic acid (NLPA) prevent β-amyloid 1-42 (Aβ42) fibrillation and Aβ42-induced human arteriole endothelial dysfunction. NLPA abolished Aβ42 fibril formation (thioflavin-T fluorescence/electron microscopy). In ex-vivo human adipose and leptomeningeal arterioles, Aβ42 impaired dilator response to acetylcholine that was reversed by NLPA; this protection was abolished by L-NG-nitroarginine methyl ester. Aβ42 reduced human umbilical vein endothelial cell NO production that was restored by NLPA. Nanoliposomes prevented Aβ42 amyloid formation, reversed Aβ42-induced human microvascular endothelial dysfunction and may be useful in Alzheimer's disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Amyloid, Alzheimer's disease, endothelial function, liposome, microvasculature |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Jan 2016 15:47 |
| Last Modified: | 05 Oct 2023 09:26 |
| DOI: | 10.1177/0271678X15610134 |
| Open Access URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC47596... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/2047663 |
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