Lipidomics applications in health, disease and nutrition research.

Murphy, Sharon A and Nicolaou, Anna ORCID: 0000-0002-1314-413X (2013) Lipidomics applications in health, disease and nutrition research. Molecular nutrition & food research, 57 (8). pp. 1336-1346.

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Abstract

The structural and functional diversity of lipids accounts for their involvement into a wide range of homeostatic processes and disease states, including lifestyle-related diseases as well as genetic conditions. Challenges presented by this diversity have been addressed to a great extent by the development of lipidomics, a platform that makes possible the detailed profiling and characterisation of lipid species present in any cell, organelle, tissue or body fluid, and allows for a wider appreciation of the biological role of lipid networks. Progress in the field of lipidomics has been greatly facilitated by recent advances in MS and includes a range of analytical platforms supporting applications spanning from qualitative and quantitative assessment of multiple species to lipid imaging. Here we review these MS techniques currently in routine use in lipidomics, alongside with new ones that have started making an impact in the field. Recent applications in health, disease and nutrition-related questions will also be discussed with a view to convey the importance of lipidomics contributions to biosciences and food technology.

Item Type:	Article
Additional Information:	alt_title: Lipidomics applications in health disease and nutrition research
Uncontrolled Keywords:	Lung, Central Nervous System, Brain, Skin, Lipids, Spectrometry, Mass, Electrospray Ionization, Food Technology, Health, Lipid Metabolism, Mass Spectrometry, Nutritional Sciences
Subjects:	?? Q1 ?? ?? QP ??
Depositing User:	Symplectic Admin
Date Deposited:	21 Jan 2016 14:56
Last Modified:	16 Mar 2024 15:16
DOI:	10.1002/mnfr.201200863
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2048043